Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943384 | 0.87 | DCTPP1 (0.55) | DCTPP1ALDH1A1RXFP1SMN1; SMN2KDM4E | |
| SCHEMBL11943477 | 0.81 | ALDH1A1 (0.50) | DCTPP1ALDH1A1RXFP1SMN1; SMN2MAPK14 | |
| SCHEMBL11943474 | 0.80 | FAAH (0.49) | DCTPP1ALDH1A1RXFP1SMN1; SMN2KDM4E | |
| SCHEMBL11943390 | 0.79 | ALDH1A1 (0.48) | DCTPP1ALDH1A1RXFP1SMN1; SMN2MAPK14 | |
| SCHEMBL11943391 | 0.77 | SMN1; SMN2 (0.47) | DCTPP1ALDH1A1RXFP1SMN1; SMN2KDM4E | |
| SCHEMBL14082616 | 0.77 | HTR1A (0.52) | DCTPP1ALDH1A1RXFP1SMN1; SMN2MAPK14 | |
| SCHEMBL11943389 | 0.76 | KMT2A (0.49) | DCTPP1ALDH1A1RXFP1SMN1; SMN2KDM4E | |
| SCHEMBL11943482 | 0.76 | GFER (0.58) | DCTPP1ALDH1A1RXFP1SMN1; SMN2MAPK14 | |
| SCHEMBL11944525 | 0.75 | ALDH1A1 (0.65) | DCTPP1ALDH1A1RXFP1SMN1; SMN2MAPK14 | |
| SCHEMBL11943422 | 0.75 | MAPK14 (0.45) | DCTPP1ALDH1A1RXFP1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115385-A2 | PIPERAZINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |