Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30492604 | 0.80 | MTNR1A (0.44) | MTNR1AMTNR1BTDP1KMT2APOLB | |
| SCHEMBL16511925 | 0.80 | MTNR1A (0.44) | MTNR1AMTNR1BTDP1KMT2APOLB | |
| SCHEMBL16225196 | 0.79 | DYRK1A (0.43) | MAPTMTNR1AMTNR1BALDH1A1RAF1 | |
| SCHEMBL31141964 | 0.77 | CYP1A2 (0.42) | MTNR1AMTNR1BALDH1A1CYP2A6KMT2A | |
| SCHEMBL11379745 | 0.77 | LMNA (0.61) | MAPTALDH1A1TSHRTDP1RAF1 | |
| SCHEMBL18544257 | 0.76 | MTNR1A (0.47) | MTNR1AMTNR1BDYRK1AMEN1KMT2A | |
| SCHEMBL12507362 | 0.76 | MTNR1A (0.50) | MAPTMTNR1AMTNR1BKMT2AATM | |
| SCHEMBL15648746 | 0.76 | MCHR1 (0.65) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL11379744 | 0.74 | LMNA (0.61) | MAPTMTNR1AMTNR1BALDH1A1TSHR | |
| SCHEMBL5365464 | 0.74 | MTNR1A (0.46) | MAPTMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1034221-B1 | DIBENZORHODAMINE DYES USEFUL AS FLUORESCENT LABELLING AGENTS | LIFE TECHNOLOGIES CORP (US) | 2014-05-14 | — | — | EP | disclosed |
| US-20110124510-A1 | METHODS OF LABELING POLYNUCLEOTIDE WITH DIBENZORHODAMINE DYES | Life Technologies Corporation (US) | 2011-05-26 | — | — | US | disclosed |
| EP-2295503-A1 | Dibenzorhodamine dyes useful as fluorescent labelling agents | Applera Corporation (US) | 2011-03-16 | — | — | EP | disclosed |
| US-7833756-B2 | Methods of labelling polynucleotides with dibenzorhodamine dyes | APPLIED BIOSYSTEMS, LLC (US) | 2010-11-16 | — | — | US | disclosed |
| EP-2221347-A1 | Sulfonated diarylrhodamine dyes | Applera Corporation (US) | 2010-08-25 | — | — | EP | disclosed |
| EP-2186801-A2 | Intermediates for synthesizing dibenzorhodamine dyes | Applera Corporation (US) | 2010-05-19 | — | — | EP | disclosed |
| EP-2179996-A1 | Sulfonated diarylrhodamine dyes | Applera Corporation (US) | 2010-04-28 | — | — | EP | disclosed |
| US-20090068751-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | APPLIED BIOSYSTEMS INC. (US) | 2009-03-12 | — | — | US | disclosed |
| US-20070099210-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | APPLERA CORPORATION (US) | 2007-05-03 | — | — | US | disclosed |
| US-7018431-B2 | Sulfonated diarylrhodamine dyes | APPLERA CORPORATION (US) | 2006-03-28 | — | — | US | disclosed |
| WO-2002044416-A2 | SULFONATED DIARYLRHODAMINE DYES AS FLUORESCENT LABELS | APPLERA CORPORATION (US) | 2002-06-06 | — | — | WO | disclosed |
| US-20020034761-A1 | Methods of labelling polynucleotides with dibenzorhodamine dyes | THE PERKIN-ELMER CORPORATION (US) | 2002-03-21 | — | — | US | disclosed |
| US-6326153-B2 | POLYNUCLEOTIDE SEQUENCING | THE PERKIN-ELMER CORPORATION | 2001-12-04 | — | — | US | disclosed |
| US-20010011139-A1 | Polynucleotides labeled with dibenzorhodamine dyes | THE PERKIN-ELMER CORPORATION | 2001-08-02 | — | — | US | disclosed |
| US-6221606-B1 | ENERGY TRANSFER DYE COMPRISING A DONOR DYE WHICH ABSORBS IGHT AND EMITS EXITATION ENERGY, AN ACCEPTOR DYE THE ABSORBS THE EXCITATION ENERGY AND FLUORESCES IN RESPONSE, AND A LINKER LINKING THE TWO DYES, AT LEAST ONE IS A DIBENZORHODAMINE DYE | THE PERKIN-ELMER CORPORATION | 2001-04-24 | — | — | US | disclosed |
| EP-1034221-A1 | DIBENZORHODAMINE DYES USEFUL AS FLUORESCENT LABELLING AGENTS | THE PERKIN-ELMER CORPORATION (US) | 2000-09-13 | — | — | EP | disclosed |
| US-6111116-A | FLUORESCENT LABELING REAGENTS | THE PERKIN-ELMER CORPORATION (US) | 2000-08-29 | — | — | US | disclosed |
| US-6051719-A | FLUORESCENT LABELING REAGENTS | THE PERKIN-ELMER CORPORATION (US) | 2000-04-18 | — | — | US | disclosed |
| US-5936087-A | FLUORESCENT LABELS; DNA SEQUENCING | THE PERKIN-ELMER CORPORATION (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1999027020-A1 | DIBENZORHODAMINE DYES USEFUL AS FLOURESCENT LABELLING AGENTS | THE PERKIN-ELMER CORPORATION (US) | 1999-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020034761-A1 | Methods of labelling polynucleotides with dibenzorhodamine dyes | NUDT1, DUT, NSUN2 | MAPT 4668/4885MTNR1A 2489/4885MTNR1B 2314/4885 |
| US-20010011139-A1 | Polynucleotides labeled with dibenzorhodamine dyes | NUDT1, DNTT, DUT | MAPT 4051/4885MTNR1A 1622/4885MTNR1B 2201/4885 |
| US-20090068751-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | NUDT1, DUT, NSUN3 | MAPT 4564/4885MTNR1A 2344/4885MTNR1B 2413/4885 |
| US-20070099210-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | NUDT1, DUT, NSUN3 | MAPT 4442/4885MTNR1A 2219/4885MTNR1B 2232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.