SCHEMBL140846

SCHEMBL140846

COC(=O)c1cc(I)ccc1N

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 7/20 0.62
ALDH1A1 P00352 6/20 0.62
KDM4E B2RXH2 6/20 0.62
MAPT P10636 4/20 0.62
HSD17B10 Q99714 3/20 0.62
HPGD P15428 3/20 0.62
TSHR P16473 3/20 0.62
ALOX15 P16050 1/20 0.62
CFTR P13569 3/20 0.56
GLA P06280 2/20 0.51
CASP1 P29466 1/20 0.51
CASP7 P55210 1/20 0.51
ATM Q13315 1/20 0.51
ABL1 P00519 1/20 0.50
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA7 P43166 2/20 0.42
CA9 Q16790 2/20 0.42
CA14 Q9ULX7 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7101138 0.98 GAA (0.60) GAAALDH1A1KDM4EMAPTHSD17B10
Ammonia Solution, Strong SCHEMBL18151874 0.98 GAA (0.60) GAAALDH1A1KDM4EMAPTHSD17B10
SCHEMBL1184918 0.85 ALDH1A1 (0.66) GAAALDH1A1KDM4EMAPTHSD17B10
SCHEMBL15326189 0.82 CA12 (0.50) GAAALDH1A1KDM4EMAPTHSD17B10
SCHEMBL31585831 0.82 CA12 (0.50) GAAALDH1A1KDM4EMAPTHSD17B10
SCHEMBL7529190 0.81 KDM4E (0.66) GAAALDH1A1KDM4EMAPTHSD17B10
SCHEMBL6168887 0.81 GAA (0.66) GAAALDH1A1KDM4EMAPTHSD17B10
SCHEMBL1277539 0.81 CA12 (0.44) GAAALDH1A1KDM4EMAPTHSD17B10
SCHEMBL6351877 0.81 GABRG2 (0.43) GAAALDH1A1KDM4EMAPTHSD17B10
SCHEMBL5621223 0.81 ALDH1A1 (0.60) GAAALDH1A1KDM4EMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 239 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117821982-A Thiourea modified imidazoline corrosion inhibitor and preparation method thereof 沧州中润化学助剂有限公司 2024-04-05 CN claimed
EP-1344775-A1 Preparation of fungicidal quinazolinones and useful intermediates E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-09-17 EP claimed
US-6166208-A Preparation of fungicidal quinazolinones and useful intermediates E. I. DU PONT DE NEMOURS AND COMPANY (US) 2000-12-26 US claimed
EP-0922037-A1 PREPARATION OF FUNGICIDAL QUINAZOLINONES AND USEFUL INTERMEDIATES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-06-16 EP claimed
WO-1997048684-A1 PREPARATION OF FUNGICIDAL QUINAZOLINONES AND USEFUL INTERMEDIATES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-12-24 WO claimed
US-12577227-B2 WDR5 inhibitors and modulators VANDERBILT UNIVERSITY (US) 2026-03-17 US disclosed
CN-119874668-A Main protease regulator and application thereof 北京昌平实验室 2025-04-25 CN disclosed
CN-119684383-A Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides 伊鲁米纳公司 2025-03-25 CN disclosed
CN-111065645-B Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides 伊鲁米纳公司 2024-12-31 CN disclosed
CN-119080751-A Heterocyclic aza-diketone derivative and preparation method and application thereof 山东大学 2024-12-06 CN disclosed
US-20240400605-A1 COMPOSITIONS AND METHODS FOR CHEMICAL CLEAVAGE AND DEPROTECTION OF SURFACE-BOUND OLIGONUCLEOTIDES ILLUMINA CAMBRIDGE LIMITED (GB) 2024-12-05 US disclosed
US-12084474-B2 Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides ILLUMINA, INC. (US) 2024-09-10 US disclosed
WO-1997048684-A1 PREPARATION OF FUNGICIDAL QUINAZOLINONES AND USEFUL INTERMEDIATES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-12-24 WO disclosed
EP-0147211-B1 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION SYNTEX (U.S.A.) INC. (US) 1990-09-12 EP disclosed
US-4710507-A Quinolone inotropic agents PFIZER INC. (US) 1987-12-01 US disclosed
US-4657893-A ANTIINFLAMMATORY AGENTS SYNTEX (U.S.A.) INC. (US) 1987-04-14 US disclosed
EP-0148623-A2 Quinolone inotropic agents Pfizer Limited (GB) 1985-07-17 EP disclosed
EP-0147211-A2 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation SYNTEX (U.S.A.) INC. (US) 1985-07-03 EP disclosed
US-4242121-A USING A PHENOXYBENZOIC ACID, ITS ESTER OR SALT IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-12-30 US disclosed
US-4000275-A BENZIMIDAZO(2,1-B) QUINAZOLIN-12(6H)ONES ELI LILLY AND COMPANY (US) 1976-12-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12084474-B2 Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides SNRPB2, NUDT21, DNMT3B GAA 1053/4885ALDH1A1 4476/4885KDM4E 3101/4885
US-12577227-B2 WDR5 inhibitors and modulators WDR1, WDR5, WDR3 GAA 4580/4885ALDH1A1 2812/4885KDM4E 1609/4885
US-20240400605-A1 COMPOSITIONS AND METHODS FOR CHEMICAL CLEAVAGE AND DEPROTECTION OF SURFACE-BOUND OLIGONUCLEOTIDES SNRPB2, NUDT21, DNMT3B GAA 1053/4885ALDH1A1 4476/4885KDM4E 3101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.