Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.39 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10879675 | 0.89 | ALDH1A1 (0.59) | ALDH1A1TDP1MAPTMAPK1TSHR | |
| SCHEMBL10623045 | 0.87 | TSHR (0.52) | ALDH1A1TDP1MAPTMAPK1L3MBTL1 | |
| SCHEMBL18676404 | 0.82 | GPR35 (0.56) | ALDH1A1TDP1MAPTMAPK1L3MBTL1 | |
| SCHEMBL6771134 | 0.81 | ALDH1A1 (0.72) | ALDH1A1TDP1MAPTMAPK1L3MBTL1 | |
| SCHEMBL15218432 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TDP1MAPTMAPK1L3MBTL1 | |
| SCHEMBL16386549 | 0.80 | MAPT (0.55) | ALDH1A1TDP1MAPTMAPK1L3MBTL1 | |
| SCHEMBL768569 | 0.78 | ALDH1A1 (0.60) | ALDH1A1TDP1MAPTMAPK1L3MBTL1 | |
| SCHEMBL6026052 | 0.77 | ALDH1A1 (0.59) | ALDH1A1TDP1TSHRHSD17B10GPR35 | |
| SCHEMBL19790249 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TDP1TSHRHSD17B10GPR35 | |
| SCHEMBL14234731 | 0.77 | GPR35 (0.43) | ALDH1A1TDP1MAPTMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194546-A1 | Pyrido-, Pyrazo- and Pyrimido-Pyrimidine Derivatives as mTOR Inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194546-A1 | Pyrido-, Pyrazo- and Pyrimido-Pyrimidine Derivatives as mTOR Inhibitors | RPS6KB1, RPS6KA1, RPS3A | ALDH1A1 4391/4885TDP1 3174/4885MAPT 4196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.