SCHEMBL1408930

SCHEMBL1408930

C=C(c1ccccc1)[Si](OC)(OC)OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
CES1 P23141 4/20 0.36
MAPT P10636 3/20 0.36
LMNA P02545 3/20 0.36
CES2 O00748 3/20 0.36
NPSR1 Q6W5P4 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
XBP1 P17861 1/20 0.36
ATM Q13315 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ALDH1A1 P00352 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
PAX8 Q06710 1/20 0.35
F2 P00734 1/20 0.34
SRC P12931 1/20 0.34
ELANE P08246 1/20 0.34
DAO P14920 1/20 0.33
NAPRT Q6XQN6 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3955257 0.88 MAPT (0.34) CES1MAPTCES2
SCHEMBL4135724 0.84 CES2 (0.35) TSHRCES1LMNACES2NPSR1
SCHEMBL3948528 0.79 TSHR (0.34) TSHRLMNAATMALDH1A1POLB
SCHEMBL10790576 0.77 TDP1 (0.40) TSHRCES1MAPTLMNANPSR1
SCHEMBL2283044 0.77 MAPT (0.43) TSHRCES1MAPTLMNACES2
SCHEMBL20583837 0.75 TSHR (0.45) TSHRCES1MAPTLMNACES2
SCHEMBL23045171 0.73 ATM (0.40) TSHRCES1MAPTLMNACES2
SCHEMBL28420886 0.73 TSHR (0.52) TSHRCES1MAPTLMNACES2
SCHEMBL7175530 0.71 ALDH1A1 (0.48) TSHRMAPTMEN1KMT2ASMN1; SMN2
SCHEMBL11654664 0.70 MAOA (0.39) TSHRCES1MAPTLMNACES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2665756-B1 METHOD FOR PRODUCING SILYL-FUNCTIONALIZED POLYOLEFINS AND SILYL-FUNCTIONALIZED POLYOLEFINS WITH SILYL MONOMER INCORPORATION DOW SILICONES CORP (US) 2022-03-30 EP disclosed
US-20200207982-A1 POLYAMIDE BLENDS DOW SILICONES CORP (US) 2020-07-02 US disclosed
US-9388265-B2 Method for producing silyl-functionalized polyolefins and silyl-functionalized polyolefins with silyl monomer incorporation DOW CORNING CORPORATION (US) 2016-07-12 US disclosed
US-9388265-B2 Method for producing silyl-functionalized polyolefins and silyl-functionalized polyolefins with silyl monomer incorporation DOW CORNING CORPORATION (US) 2016-07-12 US disclosed
US-8476375-B2 Polymers modified by silanes DOW CORNING CORPORATION (US) 2013-07-02 US disclosed
US-8476375-B2 Polymers modified by silanes DOW CORNING CORPORATION (US) 2013-07-02 US disclosed
US-20110178198-A1 POLYMERS MODIFIED BY SILANES DOW SILICONES CORPORATION 2011-07-21 US disclosed
US-20110178198-A1 POLYMERS MODIFIED BY SILANES DOW SILICONES CORPORATION 2011-07-21 US disclosed
EP-2294101-A1 POLYMERS MODIFIED BY SILANES Dow Corning Corporation (US) 2011-03-16 EP disclosed
WO-2010000479-A1 POLYMERS MODIFIED BY SILANES DOW CORNING CORPORATION (US) 2010-01-07 WO disclosed
EP-1323779-A1 Foamed polyolefin sheets with improved property spectrum Borealis GmbH (AT) 2003-07-02 EP disclosed
EP-0884355-B1 Polyolefin foams with fine cells BOREALIS GMBH (AT) 2002-07-17 EP disclosed
US-5929127-A Fine-celled polyolefin foam materials BOREALIS AG (AT) 1999-07-27 US disclosed
EP-0884355-A1 Polyolefin foams with fine cells PCD Polymere AG (AT) 1998-12-16 EP disclosed
EP-0821018-A2 Crosslinkable olefinic polymers and method for their preparation PCD-Polymere Gesellschaft m.b.H. (AT) 1998-01-28 EP disclosed