Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21283249 | 0.83 | MAPT (0.39) | LMNAPTBP1SMN1; SMN2NOS3NOS1 | |
| SCHEMBL29084105 | 0.70 | CES2 (0.42) | CA1CA2CES2CES1PTGS2 | |
| SCHEMBL18656137 | 0.68 | MAPT (0.35) | LMNASMN1; SMN2CA1CA2SIGMAR1 | |
| SCHEMBL19041598 | 0.67 | CA1 (0.52) | LMNAPTBP1SMN1; SMN2CA1CA2 | |
| SCHEMBL14095076 | 0.67 | CES2 (0.35) | SMN1; SMN2CA1CA2CES2CES1 | |
| SCHEMBL17483813 | 0.67 | SMN1; SMN2 (0.36) | LMNAPTBP1SMN1; SMN2NOS3NOS1 | |
| SCHEMBL24211178 | 0.66 | KMT2A (0.36) | LMNAPTBP1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL12801669 | 0.63 | MASP2 (0.35) | MAPTPOLBTDP1 | |
| SCHEMBL22334859 | 0.63 | ALDH1A1 (0.40) | LMNASMN1; SMN2CES2CES1MAPT | |
| SCHEMBL21428975 | 0.63 | CES2 (0.35) | LMNAPTBP1SMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099074-A1 | PHENYL- (4-PHENYL-PYRIMIDIN-2-YL) - AMINE DERIVATIVES AS IKK INHIBITORS, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS THEREOF | SANOFI-AVENTIS (FR) | 2008-08-21 | — | — | WO | disclosed |