Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 3/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177014 | 0.84 | ESR1 (0.35) | F2PRSS1PRSS3POLBGAA | |
| SCHEMBL12801196 | 0.73 | ALDH1A1 (0.45) | KDM4EPOLBGAAMAPTL3MBTL1 | |
| SCHEMBL10042500 | 0.73 | DHODH (0.38) | PRSS1PRSS3PRSS2 | |
| SCHEMBL12655080 | 0.69 | OPRM1 (0.31) | KDM4EMAPTTDP1L3MBTL1 | |
| SCHEMBL10683406 | 0.69 | MASP2 (0.41) | MASP2PLAUTHPOF2PRSS1 | |
| SCHEMBL8260838 | 0.64 | — | — | |
| SCHEMBL14094958 | 0.63 | LMNA (0.36) | POLBMAPTTDP1 | |
| SCHEMBL8004502 | 0.63 | CYP19A1 (0.38) | MASP2PLAUTHPOF2PRSS1 | |
| SCHEMBL9290333 | 0.62 | — | — | |
| SCHEMBL12435375 | 0.62 | ESR1 (0.34) | F2PRSS1PRSS3POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |