Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PLD2 | O14939 | 5/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 5/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13319038 | 0.80 | HTT (0.60) | SMN1; SMN2ALDH1A1PLD2PLD1HSD11B1 | |
| SCHEMBL13351422 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1HTTUSP2 | |
| SCHEMBL14258520 | 0.73 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1PLD2PLD1HSD11B1 | |
| SCHEMBL13319041 | 0.70 | HSD11B1 (0.47) | SMN1; SMN2ALDH1A1PLD2PLD1HSD11B1 | |
| SCHEMBL4717981 | 0.68 | CHRM1 (0.67) | SMN1; SMN2PLD2PLD1HSD11B1OPRM1 | |
| SCHEMBL3002989 | 0.64 | CHRM1 (0.66) | PLD2PLD1HSD11B1OPRM1CHRM1 | |
| SCHEMBL4920395 | 0.64 | HTT (0.74) | SMN1; SMN2ALDH1A1HSD11B1OPRM1CHRM1 | |
| SCHEMBL16434753 | 0.63 | PLD2 (0.41) | SMN1; SMN2ALDH1A1PLD2PLD1HSD11B1 | |
| SCHEMBL9974821 | 0.62 | OPRM1 (0.61) | PLD2PLD1HSD11B1OPRM1CHRM1 | |
| SCHEMBL4400779 | 0.62 | CHRM1 (0.66) | PLD2PLD1OPRM1CHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008108958-A2 | BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2008-09-12 | — | — | WO | disclosed |
| EP-1499316-B1 | (1-4-PIPERIDINYL)BENZIMIDAZOLE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS | SCHERING CORP (US) | 2008-03-19 | — | — | EP | disclosed |