Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | DHPS | P49366 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14103798 | 0.91 | MAPK1 (0.44) | L3MBTL1DHPSABCG2MAPK1ABCB1 | |
| SCHEMBL14104083 | 0.88 | L3MBTL1 (0.39) | L3MBTL1TRPA1ABCG2MAPK1KDM4E | |
| SCHEMBL14104180 | 0.87 | PIK3CA (0.47) | L3MBTL1DHPSTRPA1ABCG2MAPK1 | |
| SCHEMBL4740912 | 0.87 | ABCG2 (0.35) | DHPSABCG2MAPK1KDM4EALDH1A1 | |
| SCHEMBL14104080 | 0.86 | CYP1A2 (0.46) | L3MBTL1DHPSTRPA1ABCG2MAPK1 | |
| SCHEMBL14104442 | 0.86 | MET (0.38) | L3MBTL1TRPA1ABCG2MAPK1ABCB1 | |
| SCHEMBL14104446 | 0.85 | TRPA1 (0.41) | L3MBTL1TRPA1ABCG2MAPK1KDM4E | |
| SCHEMBL14103756 | 0.84 | TRPA1 (0.41) | L3MBTL1TRPA1MAPK1MAPTHTT | |
| SCHEMBL14104081 | 0.84 | MAPK1 (0.46) | L3MBTL1DHPSTRPA1ABCG2MAPK1 | |
| SCHEMBL14103898 | 0.83 | HDAC3 (0.38) | L3MBTL1DHPSTRPA1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |