Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DHPS | P49366 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14103798 | 0.89 | MAPK1 (0.44) | MAPK1DHPSMRGPRX1MAPTL3MBTL1 | |
| SCHEMBL14103795 | 0.84 | L3MBTL1 (0.39) | MAPK1DHPSMAPTL3MBTL1HTT | |
| SCHEMBL14104180 | 0.84 | PIK3CA (0.47) | MAPK1DHPSL3MBTL1ALDH1A1ABCG2 | |
| SCHEMBL14104079 | 0.84 | CYP1A2 (0.36) | MAPK1DHPSMAPTALDH1A1ABCG2 | |
| SCHEMBL14104080 | 0.84 | CYP1A2 (0.46) | MAPK1DHPSMAPTL3MBTL1HTT | |
| SCHEMBL14104446 | 0.82 | TRPA1 (0.41) | MAPK1MAPTL3MBTL1HTTALDH1A1 | |
| SCHEMBL14103756 | 0.81 | TRPA1 (0.41) | MAPK1MAPTL3MBTL1HTTPDGFRB | |
| SCHEMBL14103898 | 0.81 | HDAC3 (0.38) | DHPSMAPTL3MBTL1HTTPDGFRB | |
| SCHEMBL4738769 | 0.80 | MAPK1 (0.46) | MAPK1MRGPRX1MAPTL3MBTL1HTT | |
| SCHEMBL4574977 | 0.79 | MAPK1 (0.51) | MAPK1MAPTL3MBTL1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |