Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | KHK | P50053 | 7/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5095089 | 0.77 | HTR6 (0.48) | HTR6KHKELANELMNAALDH1A1 | |
| SCHEMBL5097527 | 0.74 | HTR6 (0.41) | HTR6KHKELANEALDH1A1 | |
| SCHEMBL14106935 | 0.71 | KDM4E (0.40) | HTR6LMNAKDM4EALDH1A1 | |
| SCHEMBL5095012 | 0.71 | THRB (0.38) | HTR6KHKMAPTLMNATP53 | |
| SCHEMBL5097139 | 0.70 | GHSR (0.39) | HTR6ELANEMAPTKDM4EALDH1A1 | |
| SCHEMBL5103473 | 0.68 | HTR6 (0.48) | HTR6KHKELANELMNAALDH1A1 | |
| SCHEMBL28503428 | 0.66 | ADRB1 (0.40) | KHKALDH1A1CDK4CCND3 | |
| SCHEMBL492277 | 0.66 | ADRB1 (0.40) | KHKMAPTALOX12APAF1CACNA1B | |
| SCHEMBL22789947 | 0.64 | KHK (0.47) | HTR6KHKMAPTKDM4E | |
| SCHEMBL6779177 | 0.64 | KMT2A (0.60) | MAPTLMNAKDM4EALDH1A1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101247-A2 | 6 ' SUBSTITUTED INDOLE AND INDAZOLE DERIVATIVES HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-08-21 | — | — | WO | disclosed |