Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3287322 | 0.83 | HRH3 (0.54) | HRH3CCR5SIGMAR1OPRM1HTR2A | |
| SCHEMBL16133545 | 0.80 | HRH3 (0.46) | HRH3CCR5SIGMAR1OPRM1SMN1; SMN2 | |
| SCHEMBL13227675 | 0.80 | HRH3 (0.48) | HRH3CCR5SIGMAR1OPRM1HTR2A | |
| SCHEMBL25358288 | 0.80 | HRH3 (0.48) | HRH3CCR5SIGMAR1OPRM1HTR2A | |
| SCHEMBL13518434 | 0.80 | HRH3 (0.48) | HRH3CCR5SIGMAR1OPRM1HTR2A | |
| SCHEMBL13181162 | 0.79 | HRH3 (0.54) | HRH3CCR5SIGMAR1OPRM1HTR2A | |
| SCHEMBL16328197 | 0.79 | HRH3 (0.57) | HRH3CYP2D6SMN1; SMN2ALDH1A1 | |
| SCHEMBL13152963 | 0.79 | OPRM1 (0.49) | HRH3CCR5SIGMAR1OPRM1HTR2A | |
| SCHEMBL2802804 | 0.77 | HRH3 (0.55) | HRH3CCR5SIGMAR1OPRM1ALDH1A1 | |
| SCHEMBL11544901 | 0.77 | HRH3 (0.47) | HRH3MAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134707-A1 | AZASPIRO[4.5]DECANE DERIVATIVES AND USE THEREOF | PURDUE PHARMA L.P. | 2018-05-17 | — | — | US | disclosed |
| US-9884865-B2 | Azaspiro[4.5] decane derivatives and use thereof | PURDUE PHARMA L.P. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20160207923-A1 | AZASPIRO[4.5] DECANE DERIVATIVES AND USE THEREOF | PURDUE PHARMA L.P. | 2016-07-21 | — | — | US | disclosed |
| US-8754107-B2 | Aminopyrrolidines as chemokine receptor antagonists | ABBVIE INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | ABBVIE INC. | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | MIF, CCL5, CCR2 | HRH3 506/4885CYP2D6 519/4885CCR5 6/4885 |
| US-20180134707-A1 | AZASPIRO[4.5]DECANE DERIVATIVES AND USE THEREOF | TRPV1, SCN5A, TRPA1 | HRH3 1269/4885CYP2D6 266/4885CCR5 1254/4885 |
| US-20160207923-A1 | AZASPIRO[4.5] DECANE DERIVATIVES AND USE THEREOF | TRPV1, SCN1A, SCN5A | HRH3 1337/4885CYP2D6 299/4885CCR5 1255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.