Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14114473 | 0.78 | MAP2K4 (0.41) | MAP2K4NPY5RATMNPSR1ALDH1A1 | |
| SCHEMBL14114471 | 0.75 | MAP2K4 (0.39) | MAP2K4NPY5RATMNPSR1ALDH1A1 | |
| SCHEMBL19941724 | 0.70 | ALDH1A1 (0.44) | RAF1ADORA1ADORA3ADORA2AATM | |
| SCHEMBL19926124 | 0.70 | ALDH1A1 (0.44) | RAF1ADORA1ADORA3ADORA2AATM | |
| SCHEMBL14114499 | 0.68 | KDM4E (0.40) | ALDH1A1KDM4EMAPT | |
| SCHEMBL14114507 | 0.66 | HTR7 (0.39) | MAPK14NPY5RNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14114503 | 0.66 | KIT (0.37) | MAPK14MAPK11MAPK13MAPK12ALDH1A1 | |
| SCHEMBL14114496 | 0.66 | NPC1 (0.38) | NPY5RNPSR1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14114488 | 0.66 | OPRL1 (0.33) | — | |
| SCHEMBL14114513 | 0.65 | MAP2K4 (0.48) | MAPK14MAPK11MAPK13MAPK12MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161374-A1 | Pyrazole compounds and uses related thereto | AMGEN INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161374-A1 | Pyrazole compounds and uses related thereto | AMGEN INC. | 2008-07-03 | — | — | US | disclosed |
| US-7354938-B2 | Pyrazole compounds and uses related thereto | AMGEN INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7354938-B2 | Pyrazole compounds and uses related thereto | AMGEN INC. (US) | 2008-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161374-A1 | Pyrazole compounds and uses related thereto | GOT2, PC, ABAT | MAPK14 1656/4885MAPK11 1448/4885MAPK13 1207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.