Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14114473 | 0.87 | MAP2K4 (0.41) | ALPLHSD11B1HTR1AHTR1DHTR2A | |
| SCHEMBL14114508 | 0.85 | ALOX5 (0.39) | ALPLHSD11B1HTR1AHTR1DHTR2A | |
| SCHEMBL14114517 | 0.84 | MAP2K4 (0.44) | KITALPLHSD11B1HDAC6PDGFRB | |
| SCHEMBL14114513 | 0.83 | MAP2K4 (0.48) | ALPLHSD11B1GCGRMAPK14MAPK13 | |
| SCHEMBL14114519 | 0.83 | PTGS2 (0.47) | KIT | |
| SCHEMBL14114504 | 0.82 | ABCC8 (0.42) | ALPLGCGRMAPK14MAPK13ALOX5 | |
| SCHEMBL14114496 | 0.81 | NPC1 (0.38) | HSD11B1ALDH1A1SMN1; SMN2HSD11B2MAPK1 | |
| SCHEMBL14114516 | 0.80 | NCOA1 (0.47) | ALPLHSD11B1ALDH1A1HDAC6MAPK1 | |
| SCHEMBL14114499 | 0.80 | KDM4E (0.40) | HTR1AHTR7ALDH1A1L3MBTL1 | |
| SCHEMBL14114495 | 0.80 | LRRK2 (0.39) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161374-A1 | Pyrazole compounds and uses related thereto | AMGEN INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161374-A1 | Pyrazole compounds and uses related thereto | AMGEN INC. | 2008-07-03 | — | — | US | disclosed |
| US-7354938-B2 | Pyrazole compounds and uses related thereto | AMGEN INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7354938-B2 | Pyrazole compounds and uses related thereto | AMGEN INC. (US) | 2008-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161374-A1 | Pyrazole compounds and uses related thereto | GOT2, PC, ABAT | KIT 4257/4885ALPL 2894/4885HSD11B1 241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.