Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.67 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.67 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.67 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.67 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.67 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.67 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.67 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.67 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.67 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.67 |
| ▸ | CYP4F8 | P98187 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14120619 | 0.84 | KAT6A (0.53) | CYP1A1CYP1A2CYP3A4CYP1B1CYP2E1 | |
| SCHEMBL14121066 | 0.84 | PLAU (0.55) | CYP1A1CYP1A2CYP3A4CYP1B1CYP2E1 | |
| SCHEMBL14120564 | 0.82 | PTGES2 (0.52) | CYP1A1CYP1A2CYP3A4CYP1B1CYP2E1 | |
| SCHEMBL788413 | 0.80 | ABL1 (0.54) | LMNAHDAC4HDAC2HDAC8PLAU | |
| SCHEMBL31058811 | 0.79 | CA12 (0.49) | CYP1A1CYP1A2CYP3A4CYP1B1CYP2E1 | |
| SCHEMBL18152 | 0.78 | NFE2L2 (0.53) | CA1CA2CA9ACHE | |
| SCHEMBL5542543 | 0.75 | CYP1A1 (0.80) | CYP1A1CYP1A2CYP3A4CYP1B1CYP2E1 | |
| SCHEMBL5632975 | 0.74 | CYP1A1 (0.79) | CYP1A1CYP1A2CYP3A4CYP1B1CYP2E1 | |
| SCHEMBL4167549 | 0.74 | CYP1A2 (0.67) | CYP1A1CYP1A2CYP3A4CYP1B1CYP2E1 | |
| SCHEMBL5542539 | 0.74 | CYP1A1 (0.77) | CYP1A1CYP1A2CYP3A4CYP1B1CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718264-B1 | BENZOCYCLOHEPTENE ACETIC ACIDS | HOFFMANN LA ROCHE (CH) | 2015-08-05 | — | — | EP | disclosed |
| EP-2718264-A1 | BENZOCYCLOHEPTENE ACETIC ACIDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-04-16 | — | — | EP | disclosed |
| CN-103596925-A | Benzocycloheptene acetic acids | HOFFMANN LA ROCHE | 2014-02-19 | — | — | CN | disclosed |
| WO-2012168162-A1 | BENZOCYCLOHEPTENE ACETIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-12-13 | — | — | WO | disclosed |
| US-20120309796-A1 | BENZOCYCLOHEPTENE ACETIC ACIDS | FIROOZNIA FARIBORZ (US) | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309796-A1 | BENZOCYCLOHEPTENE ACETIC ACIDS | ACAT2, ACAT1, CYP27A1 | CYP1A1 25/4885CYP1A2 45/4885CYP3A4 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.