Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.49 |
| ▸ | VEGFA | P15692 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | DBH | P09172 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8077068 | 0.80 | MAPT (0.62) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL15804049 | 0.80 | BRD4 (0.54) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL3353651 | 0.80 | KDM4E (0.63) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL15804212 | 0.79 | EGLN1 (0.57) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL28223471 | 0.75 | MAPT (0.62) | KDM4EALDH1A1MAPTTDP1EGLN1 | |
| SCHEMBL14995354 | 0.75 | MAPT (0.61) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL14015403 | 0.75 | CCR2 (0.47) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL11662580 | 0.74 | KDM4E (0.59) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL13692344 | 0.72 | DBH (0.47) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL13541051 | 0.72 | ADRA1D (0.71) | KDM4EALDH1A1SMN1; SMN2CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11583538-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | Venenum Biodesign, LLC (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210015829-A1 | CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2021-01-21 | — | — | US | disclosed |
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11583538-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | TMX1, P2RX1, TCOF1 | KDM4E 2540/4885ALDH1A1 664/4885MAPT 167/4885 |
| US-20210015829-A1 | CYCLIC TREX1 INHIBITORS | TMX1, TSNAX, TPX2 | KDM4E 2466/4885ALDH1A1 1307/4885MAPT 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.