SCHEMBL14142016

SCHEMBL14142016

CC(C)(C)OC(=O)N1CCC(c2cnc(Cn3ccc4cc([N+](=O)[O-])cc(F)c43)nc2)CC1

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.40
GPR119 Q8TDV5 9/20 0.40
DDB1 Q16531 1/20 0.40
CRBN Q96SW2 1/20 0.40
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
TLR7 Q9NYK1 1/20 0.39
WNT3A P56704 1/20 0.38
DPP4 P27487 1/20 0.38
TRPV3 Q8NET8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10203530 0.91 DDB1 (0.41) SMN1; SMN2GPR119DDB1CRBNALDH1A1
SCHEMBL10179775 0.91 TLR7 (0.39) SMN1; SMN2GPR119DDB1CRBNALDH1A1
SCHEMBL14141858 0.88 SMN1; SMN2 (0.43) SMN1; SMN2GPR119DDB1CRBNTLR7
SCHEMBL14142023 0.87 EGLN1 (0.35) ALDH1A1MAPT
SCHEMBL10179612 0.83 WNT3A (0.42) SMN1; SMN2GPR119DDB1CRBNALDH1A1
SCHEMBL14142082 0.82 GPR119 (0.49) SMN1; SMN2GPR119DDB1CRBNTLR7
SCHEMBL14142264 0.79 GPR119 (0.45) SMN1; SMN2GPR119DDB1CRBNALDH1A1
SCHEMBL10179397 0.79 TRPV3 (0.42) SMN1; SMN2GPR119DDB1CRBNTLR7
SCHEMBL10203527 0.79 DDB1 (0.44) SMN1; SMN2GPR119DDB1CRBNTLR7
SCHEMBL10180870 0.78 EGLN1 (0.35) ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190192510-A1 GPR119 AGONIST NIPPON CHEMIPHAR CO., LTD. (JP) 2019-06-27 US disclosed
EP-2532656-A1 GPR119 AGONIST Nippon Chemiphar Co., Ltd. (JP) 2012-12-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190192510-A1 GPR119 AGONIST GPR119, GPR4, GPR27 SMN1; SMN2 3543/4885GPR119 1/4885DDB1 4008/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.