Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3489715 | 0.89 | TSHR (0.44) | GHSRHDAC1EPHX2MAPK1 | |
| SCHEMBL8346749 | 0.79 | GHSR (0.47) | GHSRFAAHLMNANPC1TP53 | |
| SCHEMBL13403081 | 0.77 | HDAC1 (0.45) | GHSRHDAC1 | |
| SCHEMBL8344329 | 0.76 | KMT2A (0.50) | GHSRFAAHNPC1TP53MEN1 | |
| SCHEMBL8345080 | 0.75 | MEN1 (0.52) | GHSRFAAHMEN1KMT2AP2RX7 | |
| SCHEMBL142826 | 0.74 | GHSR (0.39) | GHSRFAAHMAPTRAB9A | |
| SCHEMBL146430 | 0.74 | GHSR (0.41) | GHSRFAAHRAB9A | |
| SCHEMBL2940952 | 0.74 | GAA (0.51) | LMNAGAAHTTMAPTNPC1 | |
| SCHEMBL8345284 | 0.74 | L3MBTL1 (0.55) | FAAHSMN1; SMN2KMT2AMAPK1TRPV1 | |
| SCHEMBL8345466 | 0.74 | FAAH (0.47) | GHSRFAAHPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075109-A1 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |