SCHEMBL14178286

SCHEMBL14178286

CNc1ncnc2c1ncn2C1OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C1O

nearest known ligand 0.79

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
P2RX3 P56373 5/20 0.79
P2RX2 Q9UBL9 5/20 0.79
P2RX4 Q99571 2/20 0.77
GPR17 Q13304 2/20 0.76
P2RY1 P47900 5/20 0.71
P2RY2 P41231 3/20 0.71
P2RY6 Q15077 1/20 0.71
P2RY12 Q9H244 1/20 0.71
P2RX1 P51575 2/20 0.70
SRC P12931 1/20 0.70
ALDH1A1 P00352 1/20 0.70
SMN1; SMN2 Q16637 1/20 0.70
NT5E P21589 1/20 0.69
RNASEL Q05823 1/20 0.68
MACROD2 A1Z1Q3 1/20 0.66
SIRT6 Q8N6T7 1/20 0.66
MACROD1 Q9BQ69 1/20 0.66
TRPM2 O94759 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3502130 1.00 P2RX3 (0.79) P2RX3P2RX2P2RX4GPR17P2RY1
SCHEMBL29353873 1.00 P2RX3 (0.79) P2RX3P2RX2P2RX4GPR17P2RY1
SCHEMBL14929510 1.00 P2RX3 (0.79) P2RX3P2RX2P2RX4GPR17P2RY1
SCHEMBL14946389 1.00 P2RX3 (0.79) P2RX3P2RX2P2RX4GPR17P2RY1
SCHEMBL624619 1.00 P2RX3 (0.79) P2RX3P2RX2P2RX4GPR17P2RY1
SCHEMBL31396265 0.99 P2RX3 (0.77) P2RX3P2RX2P2RX4GPR17P2RY1
SCHEMBL15038279 0.94 P2RX3 (0.70) P2RX3P2RX2P2RX4GPR17P2RY1
SCHEMBL25098203 0.92 P2RX3 (0.68) P2RX3P2RX2P2RX4GPR17P2RY1
SCHEMBL29793085 0.92 P2RX3 (0.68) P2RX3P2RX2P2RX4GPR17P2RY1
SCHEMBL31029196 0.92 P2RX3 (0.86) P2RX3P2RX2P2RX4GPR17P2RY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170275672-A1 CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS TRILINK BIOTECHNOLOGIES, INC. (US) 2017-09-28 US disclosed
US-20170252461-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA MODERNATX, INC. 2017-09-07 US disclosed
US-20170175129-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2017-06-22 US disclosed
US-20170136132-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2017-05-18 US disclosed
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Modema Therapeutics, Inc. (US) 2017-05-18 US disclosed
US-9631227-B2 Chemically modified ligase cofactors, donors and acceptors TRILINK BIOTECHNOLOGIES, INC. (US) 2017-04-25 US disclosed
US-20170056528-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF MODERNATX, INC. 2017-03-02 US disclosed
US-20160354491-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160354492-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20140323354-A1 Chemically Modified Ligase Cofactors, Donors and Acceptors TRILINK BIOTECHNOLOGIES, INC. (US) 2014-10-30 US disclosed
WO-2014144979-A1 CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS TRILINK BIOTECHNOLOGIES, INC. (US) 2014-09-18 WO disclosed
WO-2014093924-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2014-06-19 WO disclosed
US-8728725-B2 Chemically modified ligase cofactors, donors and acceptors TRILINK BIOTECHNOLOGIES (US) 2014-05-20 US disclosed
US-20140038181-A1 CHEMICALLY SUBSTITUTED THERMOSENSITIVE PROBES AND COFACTORS FOR HOT START LIGATION TRILINK BIOTECHNOLOGIES, INC. 2014-02-06 US disclosed
WO-2013130161-A1 METHODS OF RESPONDING TO A BIOTHREAT modeRNA Therapeutics (US) 2013-09-06 WO disclosed
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-16 US disclosed
WO-2013052523-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-04-11 WO disclosed
US-7371852-B2 Alkyl-linked nucleotide compositions SERENEX, INC. (US) 2008-05-13 US disclosed
US-7371852-B2 Alkyl-linked nucleotide compositions SERENEX, INC. (US) 2008-05-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160354492-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RX3 3314/4885P2RX2 3939/4885P2RX4 3935/4885
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 P2RX3 736/4885P2RX2 904/4885P2RX4 849/4885
US-20170056528-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 P2RX3 736/4885P2RX2 904/4885P2RX4 849/4885
US-20170136132-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 P2RX3 2081/4885P2RX2 3031/4885P2RX4 3067/4885
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RX3 3314/4885P2RX2 3939/4885P2RX4 3935/4885
US-20160354491-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RX3 3314/4885P2RX2 3939/4885P2RX4 3935/4885
US-20170175129-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 P2RX3 2081/4885P2RX2 3031/4885P2RX4 3067/4885
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 P2RX3 2081/4885P2RX2 3031/4885P2RX4 3067/4885
US-20170252461-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA RNGTT, NSUN3, CPSF6 P2RX3 3487/4885P2RX2 3712/4885P2RX4 4305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.