Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ITK | Q08881 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182724 | 1.00 | MAOA (0.52) | MAOAMAOBKCNK3KCNK9RAB9A | |
| SCHEMBL14182837 | 0.93 | RAB9A (0.44) | MAOAMAOBKCNK3KCNK9RAB9A | |
| SCHEMBL14182719 | 0.91 | MAOA (0.52) | MAOAMAOBRAB9AITKLMNA | |
| SCHEMBL14182745 | 0.91 | NAMPT (0.44) | MAOAMAOBITKMAPTKMT2A | |
| SCHEMBL14182776 | 0.91 | PTPN1 (0.46) | MAOAMAOBRAB9ANPC1MAPT | |
| SCHEMBL14182726 | 0.91 | ROCK2 (0.44) | MAOAMAOBRAB9ANPC1MAPT | |
| SCHEMBL14182720 | 0.91 | NAMPT (0.44) | MAOAMAOBITKMAPTKMT2A | |
| SCHEMBL14182752 | 0.89 | RAB9A (0.45) | MAOAMAOBRAB9ANPC1MAPT | |
| SCHEMBL14182709 | 0.89 | RAB9A (0.45) | MAOAMAOBRAB9ANPC1MAPT | |
| SCHEMBL14182765 | 0.89 | KCNQ2 (0.53) | MAOAMAOBRAB9AITKNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |