Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9967738 | 0.79 | GABRA1 (0.41) | TSHRHPGD | |
| SCHEMBL11862065 | 0.78 | ALDH1A1 (0.46) | TSHRRORCUSP2ALDH1A1GAA | |
| SCHEMBL11858312 | 0.77 | TSHR (0.38) | TSHRRORCCRHR1USP2ALDH1A1 | |
| SCHEMBL19121055 | 0.77 | TSHR (0.38) | TSHRRORCDPP7USP2ALDH1A1 | |
| SCHEMBL4905949 | 0.77 | TSHR (0.57) | TSHRRORCDPP7USP2ALDH1A1 | |
| SCHEMBL4917919 | 0.74 | RORC (0.58) | TSHRRORCDPP7USP2ALDH1A1 | |
| SCHEMBL16846285 | 0.73 | TSHR (0.38) | TSHRRORCDPP7USP2ALDH1A1 | |
| SCHEMBL22604363 | 0.73 | CYP2A6 (0.37) | TSHRRORCALDH1A1 | |
| SCHEMBL28458527 | 0.72 | TSHR (0.43) | TSHRRORCUSP2ALDH1A1GAA | |
| SCHEMBL22864668 | 0.71 | PNMT (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073350-A2 | ACETYLENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-06-19 | — | — | WO | disclosed |