Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200327 | 0.88 | NPC1 (0.46) | MLYCDNPC1JAK2RAB9APAX8 | |
| SCHEMBL14200342 | 0.85 | NPC1 (0.47) | MLYCDNPC1JAK2RAB9APAX8 | |
| SCHEMBL14200236 | 0.85 | NPC1 (0.60) | MLYCDNPC1JAK2RAB9APAX8 | |
| SCHEMBL14200328 | 0.83 | LTB4R2 (0.49) | MLYCDNPC1JAK2RAB9APAX8 | |
| SCHEMBL14230122 | 0.83 | TP53 (0.58) | MLYCDNPC1JAK2RAB9APAX8 | |
| SCHEMBL14200336 | 0.83 | TRPM8 (0.45) | MLYCDNPC1JAK2RAB9APAX8 | |
| SCHEMBL14200883 | 0.82 | ALDH1A1 (0.41) | MLYCDNPC1JAK2RAB9APAX8 | |
| SCHEMBL14200534 | 0.82 | MLYCD (0.40) | MLYCDNPC1JAK2RAB9APAX8 | |
| SCHEMBL14200376 | 0.82 | NPC1 (0.43) | MLYCDNPC1JAK2RAB9APAX8 | |
| SCHEMBL14201035 | 0.81 | MLYCD (0.38) | MLYCDNPC1JAK2RAB9APAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |