Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.38 |
| ▸ | GPX4 | P36969 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200883 | 0.87 | ALDH1A1 (0.41) | MLYCDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14201035 | 0.86 | MLYCD (0.38) | MLYCDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14200533 | 0.86 | ALDH1A1 (0.43) | MLYCDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14229032 | 0.85 | TP53 (0.48) | MLYCDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14200330 | 0.82 | MLYCD (0.44) | MLYCDTP53NPC1RAB9APAX8 | |
| SCHEMBL14201130 | 0.82 | MLYCD (0.40) | MLYCDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14229758 | 0.82 | RIPK1 (0.49) | MLYCDRIPK1NR1H2NR1H3 | |
| SCHEMBL14200328 | 0.81 | LTB4R2 (0.49) | MLYCDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14201171 | 0.80 | MLYCD (0.49) | MLYCDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14200497 | 0.80 | RIPK1 (0.36) | MLYCDALDH1A1NPC1RAB9ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |