Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1337944 | 0.85 | ADRA2A (0.40) | ESR1ESR2ALDH1A1FFAR1OPRM1 | |
| SCHEMBL1340047 | 0.85 | ESR1 (0.36) | ESR1ESR2HTR2C | |
| SCHEMBL1339435 | 0.79 | HTR6 (0.48) | — | |
| SCHEMBL29107353 | 0.75 | HRH4 (0.42) | — | |
| SCHEMBL1340184 | 0.74 | ESR1 (0.57) | ESR1ESR2MAPTOPRM1 | |
| SCHEMBL1339428 | 0.74 | ADRA2A (0.40) | OPRM1 | |
| SCHEMBL1337725 | 0.72 | SRD5A1 (0.39) | ESR1ESR2ALDH1A1 | |
| SCHEMBL1339442 | 0.72 | SRD5A1 (0.39) | ESR1ESR2ALDH1A1 | |
| SCHEMBL1340622 | 0.72 | SRD5A1 (0.39) | ESR1ESR2ALDH1A1 | |
| SCHEMBL1339993 | 0.72 | SRD5A1 (0.39) | ESR1ESR2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080091028-A1 | IMIDAZOLE-2-THIONES | ALLERGAN, INC. (US) | 2008-04-17 | — | — | US | disclosed |
| US-20080091028-A1 | IMIDAZOLE-2-THIONES | ALLERGAN, INC. (US) | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080091028-A1 | IMIDAZOLE-2-THIONES | ADRB2, ADRA2C, ADRA2B | ESR1 1836/4885ESR2 180/4885HTR2C 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.