Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200703 | 0.93 | AGTR1 (0.43) | AGTR1AGTR2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL14230028 | 0.85 | AGTR1 (0.51) | AGTR1AGTR2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL14229389 | 0.82 | AGTR1 (0.47) | AGTR1AGTR2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL14200752 | 0.81 | AGTR1 (0.38) | AGTR1AGTR2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL14200749 | 0.80 | ALDH1A1 (0.38) | AGTR1AGTR2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL9639420 | 0.76 | POLB (0.46) | AGTR1AGTR2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL9640945 | 0.75 | ALDH1A1 (0.50) | AGTR1AGTR2ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL14200877 | 0.74 | AGTR1 (0.41) | AGTR1AGTR2ALDH1A1L3MBTL1MAPT | |
| SCHEMBL3927132 | 0.71 | PDE10A (0.51) | ALDH1A1MAPK1L3MBTL1MAPTTDP1 | |
| SCHEMBL27913630 | 0.71 | AGTR1 (0.50) | AGTR1AGTR2ALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |