Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200895 | 0.91 | TSPO (0.43) | TSPOBCHEACHEHSD17B2MEN1 | |
| SCHEMBL14200838 | 0.89 | ALDH1A1 (0.45) | TSPOBCHEACHEHSD17B2MEN1 | |
| SCHEMBL14200862 | 0.89 | CTSK (0.48) | TSPOBCHEACHEHSD17B2ALDH1A1 | |
| SCHEMBL14229067 | 0.85 | TSPO (0.48) | TSPOBCHEACHEHSD17B2MEN1 | |
| SCHEMBL14200860 | 0.85 | TSPO (0.42) | TSPOBCHEACHEHSD17B2MEN1 | |
| SCHEMBL14200809 | 0.84 | MEN1 (0.42) | ACHEMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14200833 | 0.83 | EPHX2 (0.45) | TSPOBCHEACHEHSD17B2MEN1 | |
| SCHEMBL18997614 | 0.81 | HSD17B2 (0.56) | TSPOBCHEACHEHSD17B2MEN1 | |
| SCHEMBL14200797 | 0.79 | TSPO (0.50) | TSPOBCHEACHEHSD17B2MEN1 | |
| SCHEMBL14200896 | 0.78 | LMNA (0.36) | BCHEACHEMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |