Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200903 | 0.92 | RIPK1 (0.49) | RIPK1HTTALDH1A1KDM4EMITF | |
| SCHEMBL14229280 | 0.85 | RIPK1 (0.48) | RIPK1POLBAPEX1TDP1HTT | |
| SCHEMBL14200898 | 0.82 | HDAC1 (0.40) | POLBAPEX1TDP1HDAC1HDAC6 | |
| SCHEMBL14200786 | 0.81 | TSHR (0.41) | POLBAPEX1TDP1ALDH1A1HDAC1 | |
| SCHEMBL14200735 | 0.79 | APP (0.47) | HTTALDH1A1KDM4EMITFNPSR1 | |
| SCHEMBL14200919 | 0.78 | GRIN2D (0.46) | POLBAPEX1TDP1HTTALDH1A1 | |
| SCHEMBL14200864 | 0.78 | RIPK1 (0.48) | RIPK1HTTALDH1A1KDM4EMITF | |
| SCHEMBL14200851 | 0.77 | RIPK1 (0.50) | RIPK1HTTALDH1A1KDM4EMITF | |
| SCHEMBL14200878 | 0.77 | RIPK1 (0.47) | RIPK1HTTALDH1A1KDM4EMITF | |
| SCHEMBL14229063 | 0.77 | HDAC1 (0.53) | RIPK1HTTALDH1A1KDM4EMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |