Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200780 | 0.92 | HDAC6 (0.48) | HDAC1HDAC6HDAC3HDAC2NCOR2 | |
| SCHEMBL14229239 | 0.84 | HDAC1 (0.44) | HDAC1HDAC6POLBAPEX1TDP1 | |
| SCHEMBL14200852 | 0.82 | RIPK1 (0.51) | HDAC1HDAC6POLBAPEX1TDP1 | |
| SCHEMBL14200919 | 0.82 | GRIN2D (0.46) | HDAC1HDAC6POLBAPEX1TDP1 | |
| SCHEMBL14200786 | 0.82 | TSHR (0.41) | HDAC1HDAC6POLBAPEX1TDP1 | |
| SCHEMBL14200735 | 0.80 | APP (0.47) | LMNANPC1HPGDRAB9ATP53 | |
| SCHEMBL14200846 | 0.78 | TAS1R3 (0.36) | HDAC1HDAC6POLBLMNANPC1 | |
| SCHEMBL14200896 | 0.78 | LMNA (0.36) | HDAC1HDAC6POLBLMNANPC1 | |
| SCHEMBL14200765 | 0.77 | TAS1R3 (0.36) | HDAC1HDAC6POLBLMNANPC1 | |
| SCHEMBL14200827 | 0.77 | TRPM8 (0.37) | HDAC1HDAC6POLBLMNAS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |