Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358563 | 0.83 | GABRA1 (0.41) | GABRA1GABRB2POLBAKR1B1KMT2A | |
| SCHEMBL13978679 | 0.78 | GABRA1 (0.54) | GABRA1GABRB2POLBAKR1B1KMT2A | |
| SCHEMBL12931725 | 0.78 | GABRA1 (0.54) | GABRA1GABRB2POLBAKR1B1KMT2A | |
| SCHEMBL13360148 | 0.77 | PKM (0.48) | GAALMNAHTTKDM4EEGFR | |
| SCHEMBL28182839 | 0.76 | EGFR (0.42) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL30893166 | 0.75 | GABRA1 (0.70) | GABRA1GABRB2POLBAKR1B1KMT2A | |
| SCHEMBL29892631 | 0.75 | GABRA1 (1.00) | GABRA1GABRB2POLBAKR1B1KMT2A | |
| SCHEMBL252293 | 0.75 | GABRA1 (1.00) | GABRA1GABRB2POLBAKR1B1KMT2A | |
| SCHEMBL71514 | 0.75 | GABRA1 (0.70) | GABRA1GABRB2POLBAKR1B1KMT2A | |
| SCHEMBL14215922 | 0.75 | GABRA1 (0.51) | GABRA1GABRB2MAPTCNR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | TPH1, HTR1D, HTR1B | GABRA1 1636/4885GABRB2 2261/4885POLB 2855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.