Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 10/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 10/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | ACR | P10323 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13715693 | 0.81 | TAAR1 (0.43) | ALDH1A1PTGS1 | |
| SCHEMBL251558 | 0.78 | GABRA1 (0.71) | GABRA1GABRB2ALOX5CNR2ALDH1A1 | |
| SCHEMBL13421050 | 0.77 | ALOX5 (0.55) | GABRA1GABRB2ALOX5CNR2PTPN1 | |
| SCHEMBL3951418 | 0.76 | GABRA1 (0.56) | GABRA1GABRB2ALOX5CNR2ALDH1A1 | |
| SCHEMBL21358033 | 0.76 | GABRA1 (0.56) | GABRA1GABRB2ALOX5CNR2ALDH1A1 | |
| SCHEMBL2848289 | 0.76 | ALOX5 (0.56) | GABRA1GABRB2ALOX5CNR2ALDH1A1 | |
| SCHEMBL10328509 | 0.76 | GABRA1 (0.56) | GABRA1GABRB2ALOX5CNR2ALDH1A1 | |
| SCHEMBL12848922 | 0.76 | PTGDR (0.36) | GABRA1GABRB2ALOX5CNR2ALDH1A1 | |
| SCHEMBL4985231 | 0.75 | ALDH1A1 (0.58) | GABRA1GABRB2ALOX5CNR2ALDH1A1 | |
| SCHEMBL239781 | 0.75 | GABRA1 (0.63) | GABRA1GABRB2ALOX5CNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119518-A1 | 1-(Piperidin-4- Yl)-1H-Indole Derivatives | TPH1, HTR1D, HTR1B | GABRA1 1636/4885GABRB2 2261/4885ALOX5 4247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.