Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.43 |
| ▸ | AR | P10275 | 12/20 | 0.41 |
| ▸ | PGR | P06401 | 11/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SHBG | P04278 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216486 | 1.00 | PDK1 (0.43) | PDK1PDK2PDK3PDK4AR | |
| SCHEMBL14216528 | 0.86 | AR (0.57) | ARPGRNR3C2SHBG | |
| SCHEMBL14216509 | 0.81 | AR (0.39) | ARPGRNR3C2 | |
| SCHEMBL6463589 | 0.76 | AR (0.53) | PDK1PDK2PDK3PDK4AR | |
| SCHEMBL6463139 | 0.76 | AR (0.53) | PDK1PDK2PDK3PDK4AR | |
| SCHEMBL13796867 | 0.73 | PDK1 (0.43) | PDK1PDK2PDK3PDK4AR | |
| SCHEMBL13013576 | 0.72 | AR (0.75) | PDK1PDK2PDK3PDK4AR | |
| SCHEMBL16404177 | 0.70 | AR (0.78) | PDK1PDK2PDK3PDK4AR | |
| SCHEMBL14216532 | 0.70 | PGR (0.55) | ARPGRNR3C2NR3C1SLC6A4 | |
| SCHEMBL12942952 | 0.70 | AR (0.78) | PDK1PDK2PDK3PDK4AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343806-B1 | METHYLENE STEROIDS AS NOVEL ANDROGENS | ORGANON NV (NL) | 2008-05-28 | — | — | EP | disclosed |