SCHEMBL14217865

SCHEMBL14217865

OB(O)c1cc(Cl)cc(CI)c1

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 3/20 0.38
TTR P02766 1/20 0.31
LPL P06858 2/20 0.30
LIPG Q9Y5X9 2/20 0.30
IDO1 P14902 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23199573 0.81 ENPP2 (0.50) ENPP2TTRLPLLIPGIDO1
SCHEMBL12247400 0.79 LPL (0.48) ENPP2TTRLPLLIPG
SCHEMBL29209517 0.77 ENPP2 (0.52) ENPP2TTRLPLLIPG
SCHEMBL177673 0.77 ENPP2 (0.52) ENPP2TTR
SCHEMBL18908985 0.77 TSHR (0.50) IDO1
SCHEMBL12330314 0.75 CA1 (0.46) ENPP2LPLLIPG
SCHEMBL25274464 0.72 S100A9 (0.35) ENPP2
SCHEMBL18873671 0.71 HCAR1 (0.40) IDO1
SCHEMBL25280789 0.70 HSP90AB1 (0.50)
SCHEMBL2144215 0.69 ENPP2 (0.44) ENPP2TTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008063300-A2 BORONIC ACIDS AND ESTERS AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2008-05-29 WO disclosed