Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380633 | 0.83 | RAB9A (0.60) | SMN1; SMN2L3MBTL1HPGDFFAR1LMNA | |
| SCHEMBL4381243 | 0.78 | HRH3 (0.73) | HIF1AHTTALDH1A1HRH3MAPT | |
| SCHEMBL4386212 | 0.77 | HRH3 (0.72) | HIF1AALDH1A1HRH3MAPTKMT2A | |
| SCHEMBL4382306 | 0.77 | MAPT (0.55) | SMN1; SMN2LMNAALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL4377741 | 0.76 | MAPT (0.54) | SMN1; SMN2LMNAALDH1A1MAPTMEN1 | |
| SCHEMBL10162567 | 0.76 | HSD11B1 (0.72) | HSD11B1L3MBTL1RAB9AALDH1A1MAPT | |
| SCHEMBL2835721 | 0.75 | ACHE (0.62) | L3MBTL1HRH3ACHE | |
| SCHEMBL17549664 | 0.75 | KMT2A (0.71) | ALDH1A1MAPTKMT2A | |
| SCHEMBL8534233 | 0.74 | SMN1; SMN2 (0.84) | SMN1; SMN2L3MBTL1HPGDFFAR1LMNA | |
| SCHEMBL7169669 | 0.73 | ALDH1A1 (0.63) | SMN1; SMN2HPGDRAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | SMN1; SMN2 2684/4885NCOA3 679/4885HSD11B1 2071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.