Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | ANPEP | P15144 | 1/20 | 0.53 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.50 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27705268 | 0.93 | FOLH1 (0.58) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| Isobutane SCHEMBL3663817 | 0.93 | FOLH1 (0.58) | FOLH1ANPEPENPEPMEP1BMRGPRX4 | |
| SCHEMBL27705284 | 0.87 | FOLH1 (0.56) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL1777321 | 0.85 | FOLH1 (0.68) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL20880892 | 0.84 | L3MBTL1 (0.63) | FOLH1HIF1ARAB9ASMN1; SMN2 | |
| SCHEMBL1541757 | 0.84 | FOLH1 (0.61) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL371526 | 0.83 | FOLH1 (0.70) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL30791058 | 0.83 | FOLH1 (0.70) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL70351 | 0.83 | FOLH1 (0.70) | FOLH1CYP2D6CYP2C9HIF1AANPEP | |
| SCHEMBL20109815 | 0.82 | PARP1 (0.53) | FOLH1MEP1BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810067-A | A kind of preparation method of Su Woleisheng intermediate | 扬子江药业集团有限公司 | 2019-05-28 | — | — | CN | claimed |
| CN-114656461-B | Quinoline ring-containing 1,2, 4-oxadiazole substituted benzamide compound and synthetic method and application thereof | 浙江工业大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-105308048-B | Substituted 2-azabicyclic compounds and their use as orexin receptor modulators | 詹森药业有限公司 | 2019-10-08 | — | — | CN | disclosed |
| CN-106349228-B | Substituted quianzolinones and its preparation method and application | 广东东阳光药业有限公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-105461699-B | Substituted heterocyclic compound and its application method and purposes | 广东东阳光药业有限公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-107207516-B | Octahydro pyrrolo- [3,4-c] azole derivatives and application thereof | 广东东阳光药业有限公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-109810067-A | A kind of preparation method of Su Woleisheng intermediate | 扬子江药业集团有限公司 | 2019-05-28 | — | — | CN | disclosed |
| EP-2945619-B1 | CRYSTALLINE FORM OF VSN16 | UCL BUSINESS PLC (GB) | 2019-05-08 | — | — | EP | disclosed |
| CN-106674207-B | Substituted aryl heteroaryl compound and application thereof | 广东东阳光药业有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-106164047-B | 1,2- substituted cyclopentane as orexin receptor antagonists | 武田药品工业株式会社 | 2019-04-16 | — | — | CN | disclosed |
| US-20080108662-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR | CHU CHANG A | 2008-05-08 | — | — | US | disclosed |
| US-7355049-B2 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activator | HOFFMANN-LA ROCHE INC. (US) | 2008-04-08 | — | — | US | disclosed |
| EP-1745011-A2 | MODULATORS OF CANNABINOID RECEPTORS | UCL Biomedica plc (GB) | 2007-01-24 | — | — | EP | disclosed |
| US-7138530-B2 | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-11-21 | — | — | US | disclosed |
| US-20060122256-A1 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators | GILLESPIE PAUL | 2006-06-08 | — | — | US | disclosed |
| US-20050234081-A1 | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | SUBASINGHE NALIN | 2005-10-20 | — | — | US | disclosed |
| WO-2005080316-A2 | MODULATORS OF CANNABINOID RECEPTORS | UCL BIOMEDICA PLC. (GB) | 2005-09-01 | — | — | WO | disclosed |
| EP-1404652-A4 | A NOVEL ALKALOID DERIVATIVE AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CHEMTECH RES INC (KR) | 2005-06-15 | — | — | EP | disclosed |
| EP-1404652-A1 | A NOVEL ALKALOID DERIVATIVE AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Chemtech Research Incorporation (KR) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002100824-A1 | A NOVEL ALKALOID DERIVATIVE AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CHEMTECH RESEARCH INCORPORATION (KR) | 2002-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234081-A1 | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | C5, C9, C1R | FOLH1 3714/4885CYP2D6 2165/4885CYP2C9 1342/4885 |
| US-20060122256-A1 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators | GYS2, GYS1, GSK3A | FOLH1 2704/4885CYP2D6 460/4885CYP2C9 415/4885 |
| US-20080108662-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR | GYS2, PYGL, GYS1 | FOLH1 2925/4885CYP2D6 461/4885CYP2C9 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.