SCHEMBL14218452

SCHEMBL14218452

CC1(C)CC2N(C(=O)c3c[nH]c4cc(F)ccc34)CC2(C)C1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.44
HDAC1 Q13547 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
TDO2 P48775 4/20 0.39
ALDH1A1 P00352 2/20 0.37
HPGD P15428 1/20 0.37
IDO1 P14902 1/20 0.37
DRD2 P14416 1/20 0.36
HTR2A P28223 1/20 0.36
HTR7 P34969 1/20 0.36
KCNH2 Q12809 1/20 0.36
PSEN1 P49768 1/20 0.36
PSEN2 P49810 1/20 0.36
APH1B Q8WW43 1/20 0.36
NCSTN Q92542 1/20 0.36
APH1A Q96BI3 1/20 0.36
PSENEN Q9NZ42 1/20 0.36
TUBB4A P04350 1/20 0.35
TUBB P07437 1/20 0.35
TUBA3C P0DPH7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14218514 0.89 NR4A2 (0.45) CNR2IDO1KDM4E
SCHEMBL14218551 0.88 MEN1 (0.45) CNR2HDAC1HDAC6ALDH1A1HPGD
SCHEMBL14218586 0.86 TUBB1 (0.50) ALDH1A1HPGDPSEN1PSEN2APH1B
SCHEMBL3459774 0.82 LMNA (0.54) ALDH1A1HPGD
SCHEMBL14218585 0.82 F7 (0.48) HDAC1HDAC6
SCHEMBL14218512 0.81 HTR3E (0.35) CNR2ALDH1A1HTR2AHTR7KDM4E
SCHEMBL14218479 0.80 NR4A2 (0.50) ALDH1A1HPGDKDM4E
SCHEMBL14218550 0.76 CNR2 (0.45) CNR2HDAC1TUBB4ATUBBTUBA3C
SCHEMBL14218513 0.74 HPGD (0.45) HDAC1HDAC6ALDH1A1HPGDKDM4E
SCHEMBL14218481 0.74 CNR1 (0.52) CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080108598-A1 Pharmaceutical use of substituted amides NOVO NORDISK A/S (DK) 2008-05-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080108598-A1 Pharmaceutical use of substituted amides HSD11B1, HSD3B1, HSD11B2 CNR2 1206/4885HDAC1 114/4885HDAC6 331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.