SCHEMBL1421849

SCHEMBL1421849

Nc1ccc(C2CCCNC2)cc1

nearest known ligand 0.66

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 1/20 0.53
CYP2D6 P10635 1/20 0.50
SLC6A2 P23975 1/20 0.50
SLC6A4 P31645 1/20 0.50
SLC6A3 Q01959 1/20 0.50
KCNH2 Q12809 1/20 0.50
DRD2 P14416 1/20 0.47
DRD3 P35462 1/20 0.47
HTR2A P28223 1/20 0.44
CHEK1 O14757 1/20 0.43
CCNA2 P20248 1/20 0.43
CDK2 P24941 1/20 0.43
CCNA1 P78396 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12695797 1.00 HTR3A (0.53) HTR3ACYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL13505492 1.00 HTR3A (0.53) HTR3ACYP2D6SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL18045272 0.98 HTR3A (0.52) HTR3ACYP2D6SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL13505421 0.98 HTR3A (0.52) HTR3ACYP2D6SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL13505210 0.98 HTR3A (0.52) HTR3ACYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL12640788 0.90 HTR3A (0.66) HTR3ACYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL12640582 0.90 SLC18A3 (0.47) HTR3ACYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL5839498 0.90 HTR3A (0.66) HTR3ACYP2D6SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL4200479 0.88 HTR3A (0.63) HTR3A
Hydrochloric Acid SCHEMBL12505060 0.88 HTR3A (0.63) HTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 163 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119569641-A Synthesis method of nilaparib intermediate 4- (piperidin-3-yl) aniline 山东铂源药业股份有限公司 2025-03-07 CN claimed
US-11697636-B2 Substituted benzamides HOFFMANN-LA ROCHE INC. (US) 2023-07-11 US claimed
EP-3187490-B1 SUBSTITUTED BENZAMIDE DERIVATIVES HOFFMANN LA ROCHE (CH) 2022-04-06 EP claimed
CN-109134351-B Synthesis method of S-3- (4-aminophenyl) piperidine 武汉理工大学 2022-03-11 CN claimed
CN-107759506-B Preparation method of nilapabu intermediate S-3- (4-bromophenyl) piperidine 四川同晟生物医药有限公司 2021-04-23 CN claimed
US-20210061760-A1 SUBSTITUTED BENZAMIDES HOFFMANN LA ROCHE (US) 2021-03-04 US claimed
US-20200048194-A1 SUBSTITUTED BENZAMIDES F. HOFFMANN-LA ROCHE AG (CH) 2020-02-13 US claimed
CN-109134351-A S-3-(4- aminophenyl) piperidines synthetic method 武汉理工大学 2019-01-04 CN claimed
CN-107759506-A A kind of Buddhist nun draws the preparation method of (4 bromophenyl) piperidines of Pabuk intermediate S 3 四川同晟生物医药有限公司 2018-03-06 CN claimed
EP-2895477-B1 PYRAZOLE CARBOXAMIDE DERIVATIVES AS TAAR MODULATORS FOR USE IN THE TREATMENT OF SEVERAL DISORDERS, SUCH AS DEPRESSION, DIABETES AND PARKINSON'S DISEASE. HOFFMANN LA ROCHE (CH) 2017-11-01 EP claimed
EP-3187490-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2017-07-05 EP claimed
CN-106749180-A A kind of method for preparing PARP inhibitor Niraparib 南京艾德凯腾生物医药有限责任公司 2017-05-31 CN claimed
CN-106749181-A A kind of method for preparing Ni Lapani 南京艾德凯腾生物医药有限责任公司 2017-05-31 CN claimed
US-9487501-B2 Pyrazole carboxamide compounds and uses thereof HOFFMANN-LA ROCHE INC. (US) 2016-11-08 US claimed
US-9452980-B2 Substituted benzamides HOFFMANN-LA ROCHE INC. (US) 2016-09-27 US claimed
US-20150218131-A1 PYRAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF HOFFMANN-LA ROCHE INC. (US) 2015-08-06 US claimed
EP-2895477-A1 PYRAZOLE CARBOXAMIDE DERIVATIVES AS TAAR MODULATORS FOR USE IN THE TREATMENT OF SEVERAL DISORDERS, SUCH AS DEPRESSION, DIABETES AND PARKINSON'S DISEASE F. Hoffmann-La Roche AG (CH) 2015-07-22 EP claimed
WO-2014041007-A1 PYRAZOLE CARBOXAMIDE DERIVATIVES AS TAAR MODULATORS FOR USE IN THE TREATMENT OF SEVERAL DISORDERS, SUCH AS DEPRESSION, DIABETES AND PARKINSON'S DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2014-03-20 WO claimed
EP-2516392-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2012-10-31 EP claimed
CN-122059869-A Method for synthesizing Nilapachone key intermediate 南京正大天晴制药有限公司 2026-05-19 CN disclosed
CN-120682137-A Preparation method of nilaparib intermediate (S) -3- (4-aminophenyl) piperidine-1-tert-butyl formate 南通常佑药业科技有限公司 2025-09-23 CN disclosed
CN-120682137-A Preparation method of nilaparib intermediate (S) -3- (4-aminophenyl) piperidine-1-tert-butyl formate 南通常佑药业科技有限公司 2025-09-23 CN disclosed
CN-119569641-A Synthesis method of nilaparib intermediate 4- (piperidin-3-yl) aniline 山东铂源药业股份有限公司 2025-03-07 CN disclosed
US-20240368118-A1 CEREBLON BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH CELGENE CORPORATION 2024-11-07 US disclosed
CN-117964546-B Preparation method of nilaparib intermediate 成都硕德药业有限公司 2024-06-11 CN disclosed
CN-117964546-A Preparation method of nilaparib intermediate 成都硕德药业有限公司 2024-05-03 CN disclosed
WO-2024044657-A1 BIOCATALYSTS AND METHODS THEREOF TESARO, INC. (US) 2024-02-29 WO disclosed
CN-117538434-A Detection method of nilaparib intermediate 苏州正济医药研究有限公司 2024-02-09 CN disclosed
US-11697636-B2 Substituted benzamides HOFFMANN-LA ROCHE INC. (US) 2023-07-11 US disclosed
EP-3668857-B1 PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF TEVA PHARMACEUTICALS INT GMBH (CH) 2023-07-05 EP disclosed
EP-3668857-B1 PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF TEVA PHARMACEUTICALS INT GMBH (CH) 2023-07-05 EP disclosed
CN-113637002-B Preparation method of Nilaparib 天津太平洋化学制药有限公司 2022-09-30 CN disclosed
US-20220280527-A1 TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT PURDUE PHARMA L.P. (US) 2022-09-08 US disclosed
CN-106008460-B Pharmaceutically acceptable salts of 2- {4- [ (3S) -piperidin-3-yl ] phenyl } -2H-indazole-7-carboxamide 默沙东公司 2022-08-12 CN disclosed
EP-3694836-B1 PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF ZAI LAB SHANGHAI CO LTD (CN) 2022-06-15 EP disclosed
EP-3694836-B1 PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF ZAI LAB SHANGHAI CO LTD (CN) 2022-06-15 EP disclosed
CN-109134351-B Synthesis method of S-3- (4-aminophenyl) piperidine 武汉理工大学 2022-03-11 CN disclosed
CN-109134351-B Synthesis method of S-3- (4-aminophenyl) piperidine 武汉理工大学 2022-03-11 CN disclosed
CN-109134351-B Synthesis method of S-3- (4-aminophenyl) piperidine 武汉理工大学 2022-03-11 CN disclosed
CN-113637002-A Preparation method of Nilaparib 天津太平洋化学制药有限公司 2021-11-12 CN disclosed
CN-107759506-B Preparation method of nilapabu intermediate S-3- (4-bromophenyl) piperidine 四川同晟生物医药有限公司 2021-04-23 CN disclosed
CN-107759506-B Preparation method of nilapabu intermediate S-3- (4-bromophenyl) piperidine 四川同晟生物医药有限公司 2021-04-23 CN disclosed
US-20210061760-A1 SUBSTITUTED BENZAMIDES HOFFMANN LA ROCHE (US) 2021-03-04 US disclosed
US-10927077-B2 Process for preparing intermediate of anti-tumor drug niraparib and intermediate thereof ZAI LAB (SHANGHAI) CO., LTD. (CN) 2021-02-23 US disclosed
US-10927077-B2 Process for preparing intermediate of anti-tumor drug niraparib and intermediate thereof ZAI LAB (SHANGHAI) CO., LTD. (CN) 2021-02-23 US disclosed
US-10927095-B2 Processes for the preparation of Niraparib and intermediates thereof TEVA PHARMACEUTICALS INTERNATIONAL GMBH 2021-02-23 US disclosed
US-10927095-B2 Processes for the preparation of Niraparib and intermediates thereof TEVA PHARMACEUTICALS INTERNATIONAL GMBH 2021-02-23 US disclosed
US-20200385350-A1 PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF ZAI LAB (SHANGHAI) CO., LTD. (CN) 2020-12-10 US disclosed
US-20200385350-A1 PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF ZAI LAB (SHANGHAI) CO., LTD. (CN) 2020-12-10 US disclosed
US-10752624-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2020-08-25 US disclosed
EP-3668857-A1 PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF Teva Pharmaceuticals International GmbH (CH) 2020-06-24 EP disclosed
US-20200190056-A1 PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF ASSIA CHEMICAL INDUSTRIES LTD. (IL) 2020-06-18 US disclosed
US-20200190056-A1 PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF ASSIA CHEMICAL INDUSTRIES LTD. (IL) 2020-06-18 US disclosed
CN-109456253-B Method for synthesizing (S) -3- (4-bromophenyl) -piperidine or salt thereof through chiral induction 上海博璞诺科技发展有限公司 2020-04-07 CN disclosed
US-20200048194-A1 SUBSTITUTED BENZAMIDES F. HOFFMANN-LA ROCHE AG (CH) 2020-02-13 US disclosed
EP-3536690-A1 AMIDE SUBSTITUTED INDAZOLES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS MSD Italia S.r.l. (IT) 2019-09-11 EP disclosed
US-20190201410-A1 TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT PURDUE PHARMA L.P. (US) 2019-07-04 US disclosed
WO-2019072237-A1 PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF ZAI LAB (SHANGHAI) CO., LTD. (CN) 2019-04-18 WO disclosed
EP-3463359-A1 TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT Purdue Pharma LP (US) 2019-04-10 EP disclosed
EP-2805945-B1 Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors MSD ITALIA SRL (IT) 2019-04-03 EP disclosed
EP-2805945-B1 Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors MSD ITALIA SRL (IT) 2019-04-03 EP disclosed
WO-2019036441-A1 PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF TEVA PHARMACEUTICALS USA, INC. (US) 2019-02-21 WO disclosed
WO-2019036441-A1 PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF TEVA PHARMACEUTICALS USA, INC. (US) 2019-02-21 WO disclosed
CN-109265390-A A kind of preparation method and intermediate of the intermediate for synthesizing antineoplastic medicament niraparib 再鼎医药(上海)有限公司 2019-01-25 CN disclosed
CN-109134351-A S-3-(4- aminophenyl) piperidines synthetic method 武汉理工大学 2019-01-04 CN disclosed
CN-109134351-A S-3-(4- aminophenyl) piperidines synthetic method 武汉理工大学 2019-01-04 CN disclosed
CN-109134351-A S-3-(4- aminophenyl) piperidines synthetic method 武汉理工大学 2019-01-04 CN disclosed
CN-108997313-A PARP inhibitor key intermediate and preparation method thereof 常州制药厂有限公司 2018-12-14 CN disclosed
US-20180305356-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2018-10-25 US disclosed
EP-2675793-B1 FAK INHIBITORS CANCER THERAPEUTICS CRC PTY LTD (AU) 2018-08-08 EP disclosed
US-10000482-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2018-06-19 US disclosed
CN-107759506-A A kind of Buddhist nun draws the preparation method of (4 bromophenyl) piperidines of Pabuk intermediate S 3 四川同晟生物医药有限公司 2018-03-06 CN disclosed
WO-2017210616-A1 TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT PURDUE PHARMA L.P. (US) 2017-12-07 WO disclosed
EP-2895477-B1 PYRAZOLE CARBOXAMIDE DERIVATIVES AS TAAR MODULATORS FOR USE IN THE TREATMENT OF SEVERAL DISORDERS, SUCH AS DEPRESSION, DIABETES AND PARKINSON'S DISEASE. HOFFMANN LA ROCHE (CH) 2017-11-01 EP disclosed
US-9802937-B2 Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-10-31 US disclosed
CN-106986832-A Vegfr3 inhibitor 癌症治疗合作研究中心有限公司 2017-07-28 CN disclosed
EP-3187490-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2017-07-05 EP disclosed
CN-106854176-A A kind of method for preparing Ni Lapani tosilate monohydrates 南京艾德凯腾生物医药有限责任公司 2017-06-16 CN disclosed
CN-106749180-A A kind of method for preparing PARP inhibitor Niraparib 南京艾德凯腾生物医药有限责任公司 2017-05-31 CN disclosed
CN-106749181-A A kind of method for preparing Ni Lapani 南京艾德凯腾生物医药有限责任公司 2017-05-31 CN disclosed
US-9637491-B2 Pyrazolo[4,3-D]pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-05-02 US disclosed
CN-106432054-A Method for preparing 4-(piperidine-3-yl)aniline 青岛云天生物技术有限公司 2017-02-22 CN disclosed
CN-106432054-A Method for preparing 4-(piperidine-3-yl)aniline 青岛云天生物技术有限公司 2017-02-22 CN disclosed
CN-106432055-A Preparation method of niraparib intermediate 4-(piperidyl-3-yl)aniline 青岛辰达生物科技有限公司 2017-02-22 CN disclosed
CN-106432055-A Preparation method of niraparib intermediate 4-(piperidyl-3-yl)aniline 青岛辰达生物科技有限公司 2017-02-22 CN disclosed
US-9499535-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2016-11-22 US disclosed
US-9487501-B2 Pyrazole carboxamide compounds and uses thereof HOFFMANN-LA ROCHE INC. (US) 2016-11-08 US disclosed
CN-106008460-A Pharmaceutically acceptable salts of 2-{4-[(3S)-piperidin-3- yl]phenyl} -2H-indazole-7-carboxamide 默沙东有限公司 2016-10-12 CN disclosed
US-9452980-B2 Substituted benzamides HOFFMANN-LA ROCHE INC. (US) 2016-09-27 US disclosed
US-20160264596-A1 SUBSTITUTED BENZAMIDES HOFFMANN-LA ROCHE INC. 2016-09-15 US disclosed
US-9421205-B2 FAK inhibitors Cancer Therapeutics CRC Pty Ltd. (AU) 2016-08-23 US disclosed
US-9421205-B2 FAK inhibitors Cancer Therapeutics CRC Pty Ltd. (AU) 2016-08-23 US disclosed
US-9421205-B2 FAK inhibitors Cancer Therapeutics CRC Pty Ltd. (AU) 2016-08-23 US disclosed
EP-2699572-B1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2016-08-10 EP disclosed
US-9266864-B2 VEGFR3 inhibitors CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2016-02-23 US disclosed
US-9266864-B2 VEGFR3 inhibitors CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2016-02-23 US disclosed
US-9266864-B2 VEGFR3 inhibitors CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2016-02-23 US disclosed
US-9238644-B2 VEGFR3 inhibitors CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2016-01-19 US disclosed
US-9238644-B2 VEGFR3 inhibitors CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2016-01-19 US disclosed
US-9238644-B2 VEGFR3 inhibitors CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2016-01-19 US disclosed
US-20160009686-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2016-01-14 US disclosed
US-20160009686-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2016-01-14 US disclosed
US-20160009686-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2016-01-14 US disclosed
EP-2699579-B1 PYRAZOLO[4,3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-10-07 EP disclosed
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-24 US disclosed
US-20150259340-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-17 US disclosed
US-20150231135-A1 FAK INHIBITORS Cancer Therapeutics CRC Pty Ltd. (AU) 2015-08-20 US disclosed
US-20150231135-A1 FAK INHIBITORS Cancer Therapeutics CRC Pty Ltd. (AU) 2015-08-20 US disclosed
US-20150231135-A1 FAK INHIBITORS Cancer Therapeutics CRC Pty Ltd. (AU) 2015-08-20 US disclosed
US-20150225377-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2015-08-13 US disclosed
US-20150225377-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2015-08-13 US disclosed
US-20150225377-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2015-08-13 US disclosed
US-20150218131-A1 PYRAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF HOFFMANN-LA ROCHE INC. (US) 2015-08-06 US disclosed
EP-2240466-B1 PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3- YL]PHENYL} -2H-INDAZOLE-7-CARBOXAMIDE MERCK SHARP & DOHME (GB) 2015-07-29 EP disclosed
EP-2895477-A1 PYRAZOLE CARBOXAMIDE DERIVATIVES AS TAAR MODULATORS FOR USE IN THE TREATMENT OF SEVERAL DISORDERS, SUCH AS DEPRESSION, DIABETES AND PARKINSON'S DISEASE F. Hoffmann-La Roche AG (CH) 2015-07-22 EP disclosed
EP-2885291-A1 VEGFR3 INHIBITORS Cancer Therapeutics Crc Pty Limited (AU) 2015-06-24 EP disclosed
US-9012461-B2 FAK inhibitors CANCER THERAPEUTICS CRC PTY LTD (AU) 2015-04-21 US disclosed
US-9012461-B2 FAK inhibitors CANCER THERAPEUTICS CRC PTY LTD (AU) 2015-04-21 US disclosed
US-9012461-B2 FAK inhibitors CANCER THERAPEUTICS CRC PTY LTD (AU) 2015-04-21 US disclosed
EP-2805945-A1 Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors MSD Italia S.r.l. (IT) 2014-11-26 EP disclosed
US-20140163026-A1 8-ETHYL-6-(ARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER AFRAXIS HOLDINGS, INC. (US) 2014-06-12 US disclosed
WO-2014060112-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 WO disclosed
US-20140080798-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2014-03-20 US disclosed
US-20140080798-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2014-03-20 US disclosed
US-20140080798-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2014-03-20 US disclosed
WO-2014041007-A1 PYRAZOLE CARBOXAMIDE DERIVATIVES AS TAAR MODULATORS FOR USE IN THE TREATMENT OF SEVERAL DISORDERS, SUCH AS DEPRESSION, DIABETES AND PARKINSON'S DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2014-03-20 WO disclosed
US-20140073620-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2014-03-13 US disclosed
US-20140073620-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2014-03-13 US disclosed
US-20140073620-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2014-03-13 US disclosed
WO-2014026243-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2014-02-20 WO disclosed
WO-2014027199-A1 FAK AND FLT3 INHIBITORS CANCER THERAPEUTICS CRC PTY LTD (AU) 2014-02-20 WO disclosed
WO-2014026243-A1 VEGFR3 INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2014-02-20 WO disclosed
CN-103596951-A 8-ethyl-6-(aryl)pyrido [2,3-d]pyrimidin-7(8h)-ones for the treatment of nervous system disorders and cancer AFRAXIS INC 2014-02-19 CN disclosed
EP-2675793-A1 FAK INHIBITORS Cancer Therapeutics Crc Pty Limited (AU) 2013-12-25 EP disclosed
US-20130324532-A1 FAK INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2013-12-05 US disclosed
CN-101578279-B Amide substituted indazoles as poly (ADP ribose) polymerase (PARP) inhibitors ANGELETTI P IST RICHERCHE BIO 2013-07-17 CN disclosed
US-8436185-B2 Pharmaceutically acceptable salts of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide MERCK SHARP & DOHME CORP. (US) 2013-05-07 US disclosed
WO-2013043232-A2 8-ETHYL-6-(ARYL)PYRIDO [2,3-D]PYRIMIDIN-7(8H) -ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER AFRAXIS, INC. (US) 2013-03-28 WO disclosed
US-20130017194-A1 FAK INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2013-01-17 US disclosed
US-20130017194-A1 FAK INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2013-01-17 US disclosed
US-20130017194-A1 FAK INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2013-01-17 US disclosed
US-20120329785-A1 Novel kinase inhibitors ORIGENIS GMBH (DE) 2012-12-27 US disclosed
US-20120329780-A1 Novel kinase inhibitors ORIGENIS GMBH (DE) 2012-12-27 US disclosed
WO-2012168260-A1 PYRAZOLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2012-12-13 WO disclosed
EP-2516392-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2012-10-31 EP disclosed
WO-2012110773-A1 FAK INHIBITORS CANCER THERAPEUTICS CRC PTY LIMITED (AU) 2012-08-23 WO disclosed
US-8071623-B2 Anticancer, antiinflammatory, antitumor agents, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage; protecting against the toxicity of chemotherapy; 2-(4-Piperidin-3-ylphenyl)2H-indazole-7-carboxamide INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA 2011-12-06 US disclosed
WO-2011076678-A1 SUBSTITUTED BENZAMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2011-06-30 WO disclosed
EP-2336120-A1 Combinations containing amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors Istituto di ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) 2011-06-22 EP disclosed
EP-2336120-A1 Combinations containing amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors Istituto di ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) 2011-06-22 EP disclosed
EP-2109608-B1 AMIDE SUBSTITUTED INDAZOLES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS ANGELETTI P IST RICHERCHE BIO (IT) 2011-03-23 EP disclosed
EP-2109608-B1 AMIDE SUBSTITUTED INDAZOLES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS ANGELETTI P IST RICHERCHE BIO (IT) 2011-03-23 EP disclosed
CN-101932572-A Pharmaceutically acceptable salts of 2- {4- [ (3S) -piperidin-3-yl ] phenyl } -2H-indazole-7-carboxamide MERCK & CO INC 2010-12-29 CN disclosed
US-20100286203-A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF 2--2H-INDAZOLE-7-CARBOXAMIDE MERCK SHARP & DOHME LLC 2010-11-11 US disclosed
EP-2240466-A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3- YL]PHENYL} -2H-INDAZOLE-7-CARBOXAMIDE Merck Sharp & Dohme Limited (GB) 2010-10-20 EP disclosed
CN-101578279-A Amide substituted indazoles as poly (ADP ribose) polymerase (PARP) inhibitors ANGELETTI P IST RICHERCHE BIO (IT) 2009-11-11 CN disclosed
EP-2109608-A1 AMIDE SUBSTITUTED INDAZOLES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) 2009-10-21 EP disclosed
WO-2009087381-A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3- YL]PHENYL} -2H-INDAZOLE-7-CARBOXAMIDE MERCK SHARP & DOHME LTD (GB) 2009-07-16 WO disclosed
WO-2008084261-A1 AMIDE SUBSTITUTED INDAZOLES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2008-07-17 WO disclosed
WO-2008084261-A1 AMIDE SUBSTITUTED INDAZOLES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2008-07-17 WO disclosed
US-20080167345-A1 Anticancer, antiinflammatory, antitumor agents, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage; protecting against the toxicity of chemotherapy; 2-(4-Piperidin-3-ylphenyl)2H-indazole-7-carboxamide MERCK SHARP & DOHME LLC 2008-07-10 US disclosed
US-20080167345-A1 Anticancer, antiinflammatory, antitumor agents, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage; protecting against the toxicity of chemotherapy; 2-(4-Piperidin-3-ylphenyl)2H-indazole-7-carboxamide MERCK SHARP & DOHME LLC 2008-07-10 US disclosed
WO-2007140222-A2 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2007-12-06 WO disclosed
WO-2007140222-A2 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2007-12-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (29 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080167345-A1 Anticancer, antiinflammatory, antitumor agents, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage; protecting against the toxicity of chemotherapy; 2-(4-Piperidin-3-ylphenyl)2H-indazole-7-carboxamide PARP1, PARP2, PARP11 HTR3A 2293/4885CYP2D6 4188/4885SLC6A2 4326/4885
US-20130017194-A1 FAK INHIBITORS PTK2, CTTN, SRC HTR3A 2064/4885CYP2D6 4301/4885SLC6A2 4828/4885
US-20150225377-A1 VEGFR3 INHIBITORS FLT4, FLT1, KDR HTR3A 933/4885CYP2D6 2324/4885SLC6A2 3741/4885
US-10927095-B2 Processes for the preparation of Niraparib and intermediates thereof PARP1, PARP2, PARP3 HTR3A 3609/4885CYP2D6 712/4885SLC6A2 2935/4885
US-20150259340-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK HTR3A 2847/4885CYP2D6 3687/4885SLC6A2 2761/4885
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS LRRK2, MYLK2, MYLK HTR3A 1320/4885CYP2D6 2362/4885SLC6A2 3597/4885
US-20190201410-A1 TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT TAAR1, TAAR5, OPRL1 HTR3A 79/4885CYP2D6 2615/4885SLC6A2 68/4885
US-20160264596-A1 SUBSTITUTED BENZAMIDES TAAR1, TAAR5, NPY1R HTR3A 248/4885CYP2D6 593/4885SLC6A2 59/4885
US-20160009686-A1 VEGFR3 INHIBITORS FLT4, FLT1, KDR HTR3A 1037/4885CYP2D6 2507/4885SLC6A2 4523/4885
US-20220280527-A1 TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT TAAR1, TAAR5, OPRL1 HTR3A 74/4885CYP2D6 2946/4885SLC6A2 100/4885
US-20180305356-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK HTR3A 2847/4885CYP2D6 3687/4885SLC6A2 2761/4885
US-10927077-B2 Process for preparing intermediate of anti-tumor drug niraparib and intermediate thereof PARP1, PARP2, TOP2B HTR3A 4265/4885CYP2D6 1405/4885SLC6A2 4427/4885
US-20100286203-A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF 2--2H-INDAZOLE-7-CARBOXAMIDE PARP1, PARP12, PARP15 HTR3A 2217/4885CYP2D6 2747/4885SLC6A2 3683/4885
US-20210061760-A1 SUBSTITUTED BENZAMIDES TAAR1, TAAR5, NPY1R HTR3A 248/4885CYP2D6 593/4885SLC6A2 59/4885
US-20120329780-A1 Novel kinase inhibitors LRRK2, MYLK2, MYLK HTR3A 2847/4885CYP2D6 3687/4885SLC6A2 2761/4885
US-20120329785-A1 Novel kinase inhibitors LRRK2, MYLK2, MYLK3 HTR3A 3550/4885CYP2D6 4479/4885SLC6A2 1855/4885
US-20130324532-A1 FAK INHIBITORS PTK2, CTTN, SRC HTR3A 2064/4885CYP2D6 4301/4885SLC6A2 4828/4885
US-20200385350-A1 PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF PARP1, PARP2, TOP2B HTR3A 4265/4885CYP2D6 1405/4885SLC6A2 4427/4885
US-20200190056-A1 PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF PARP1, PARP2, PARP3 HTR3A 3609/4885CYP2D6 712/4885SLC6A2 2935/4885
US-20240368118-A1 CEREBLON BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH CRBN, AR, SHBG HTR3A 417/4885CYP2D6 4807/4885SLC6A2 3733/4885
US-20200048194-A1 SUBSTITUTED BENZAMIDES TAAR1, TAAR5, NPY1R HTR3A 248/4885CYP2D6 593/4885SLC6A2 59/4885
US-20140080798-A1 VEGFR3 INHIBITORS FLT4, FLT1, KDR HTR3A 1273/4885CYP2D6 2426/4885SLC6A2 4545/4885
US-20150218131-A1 PYRAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF HCRTR1, TAAR1, HCRTR2 HTR3A 55/4885CYP2D6 555/4885SLC6A2 203/4885
US-10000482-B2 Kinase inhibitors LRRK2, MYLK2, MYLK HTR3A 2474/4885CYP2D6 3642/4885SLC6A2 2644/4885
US-11697636-B2 Substituted benzamides TAAR1, TAAR5, NPY1R HTR3A 248/4885CYP2D6 593/4885SLC6A2 59/4885
US-20140073620-A1 VEGFR3 INHIBITORS FLT4, FLT1, KDR HTR3A 1037/4885CYP2D6 2507/4885SLC6A2 4523/4885
US-10752624-B2 Kinase inhibitors LRRK2, MYLK2, MYLK HTR3A 2474/4885CYP2D6 3642/4885SLC6A2 2644/4885
US-20150231135-A1 FAK INHIBITORS PTK2, CTTN, SRC HTR3A 1555/4885CYP2D6 4401/4885SLC6A2 4758/4885
US-20140163026-A1 8-ETHYL-6-(ARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER PAK2, PAK1, PAK6 HTR3A 1032/4885CYP2D6 3804/4885SLC6A2 2526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.