Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GNAI3 | P08754 | 8/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19525548 | 0.83 | NPC1 (0.39) | MEN1KMT2AMAPTPOLBGNAI3 | |
| SCHEMBL19621275 | 0.79 | NPC1 (0.39) | MEN1KMT2AMAPTPOLBNPC1 | |
| SCHEMBL20034969 | 0.78 | MEN1 (0.71) | MEN1KMT2AMAPTPOLBGNAI3 | |
| SCHEMBL21308333 | 0.77 | MAPT (0.43) | MEN1KMT2AMAPTPOLBNPC1 | |
| SCHEMBL27399806 | 0.76 | GNAI3 (0.47) | MEN1KMT2APOLBGNAI3GNAO1 | |
| SCHEMBL25824843 | 0.76 | NPC1 (0.47) | MEN1KMT2AMAPTPOLBNPC1 | |
| SCHEMBL20633386 | 0.74 | PHGDH (0.39) | MEN1KMT2AMAPTPOLBNPC1 | |
| SCHEMBL3663914 | 0.74 | MEN1 (0.81) | MEN1KMT2AMAPTPOLBGNAI3 | |
| SCHEMBL5141324 | 0.74 | L3MBTL1 (0.59) | MEN1KMT2AGNAI3GNAI1NPC1 | |
| SCHEMBL22047826 | 0.73 | MEN1 (0.36) | MEN1KMT2AMAPTPOLBGNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354946-B2 | prominent growth inhibitory activity against tumor cells; cyclin dependent kinase inhibitors; colon cancer; N'-(3-t-butylisoindolino[3,2-b]oxazolidin-4-on-8-yl)-N-(4-(N-benzylpyrrolidin-3-yl)pyridin-2-yl)urea | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-04-08 | — | — | US | disclosed |