SCHEMBL142273

SCHEMBL142273

COCCOCCOc1cc(C)c(C#Cc2cc(F)c(C#N)c(F)c2)c(C)c1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
APP P05067 7/20 0.34
SQOR Q9Y6N5 1/20 0.33
KDM4E B2RXH2 3/20 0.32
GAA P10253 2/20 0.32
HPGD P15428 2/20 0.32
AR P10275 1/20 0.32
FFAR1 O14842 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
MGAT2 Q10469 1/20 0.32
RECQL P46063 1/20 0.32
LMNA P02545 1/20 0.31
ALDH1A1 P00352 1/20 0.31
ALOX15 P16050 1/20 0.31
HSD17B10 Q99714 1/20 0.31
APOBEC3G Q9HC16 1/20 0.31
TRPV4 Q9HBA0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL140747 0.91 APP (0.36) APPSQORKDM4EARMGAT2
SCHEMBL14964489 0.88 KDM4E (0.42) APPKDM4EGAAHPGDMGAT2
SCHEMBL12979327 0.86 SQOR (0.35) SQORKDM4EGAAHPGDAR
SCHEMBL12477629 0.84 MAPT (0.41) APPKDM4ETDP1RECQLALDH1A1
SCHEMBL13021574 0.84 FFAR1 (0.41) SQORKDM4EARFFAR1TDP1
SCHEMBL19462692 0.81 HPGD (0.42) KDM4EGAAHPGDALDH1A1
SCHEMBL15079420 0.81 RARB (0.40) APPKDM4EGAAHPGDFFAR1
SCHEMBL12979451 0.80 POLB (0.38) APPSQORKDM4EGAAHPGD
SCHEMBL20546963 0.80 TRPV4 (0.42) SQORKDM4EHPGDARFFAR1
SCHEMBL142121 0.79 RARB (0.44) APPKDM4EGAAHPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013075050-A1 PHOTOREFRACTIVE DEVICE CONTAINING CARBON NANOTUBE-DOPED POLYMER LAYERS AND ITS MANUFACTURING METHOD NITTO DENKO CORPORATION (JP) 2013-05-23 WO disclosed
WO-2013075050-A1 PHOTOREFRACTIVE DEVICE CONTAINING CARBON NANOTUBE-DOPED POLYMER LAYERS AND ITS MANUFACTURING METHOD NITTO DENKO CORPORATION (JP) 2013-05-23 WO disclosed
US-8420235-B2 Emissive diaryl acetylenes NITTO DENKO CORPORATION (JP) 2013-04-16 US disclosed
US-8420235-B2 Emissive diaryl acetylenes NITTO DENKO CORPORATION (JP) 2013-04-16 US disclosed
WO-2012116071-A1 PHOTOREFRACTIVE COMPOSITION COMPRISING ELECTROLYTES IN A PHOTOREFRACTIVE LAYER AND METHOD OF MAKING THEREOF NITTO DENKO CORPORATION (JP) 2012-08-30 WO disclosed
US-20120058418-A1 THREE-DIMENSIONAL HOLOGRAPHIC DISPLAY DEVICE NITTO DENKO CORPORATION (JP) 2012-03-08 US disclosed
US-20120058418-A1 THREE-DIMENSIONAL HOLOGRAPHIC DISPLAY DEVICE NITTO DENKO CORPORATION (JP) 2012-03-08 US disclosed
US-20100308716-A1 EMISSIVE DIARYL ACETYLENES NITTO DENKO CORPORATION (JP) 2010-12-09 US disclosed
WO-2010141754-A1 EMISSIVE DIARYL ACETYLENES NITTO DENKO CORPORATION (JP) 2010-12-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100308716-A1 EMISSIVE DIARYL ACETYLENES B3GNT2, GSTO1, NAT1 APP 2230/4885SQOR 148/4885KDM4E 2553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.