Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL205280 | 0.83 | GSK3B (0.80) | GSK3BPTPN1HDAC3HDAC4HDAC1 | |
| SCHEMBL9237039 | 0.82 | GSK3B (0.64) | GSK3BPTPN1CES2CES1THRA | |
| SCHEMBL6816324 | 0.82 | GSK3B (0.64) | GSK3BPTPN1CES2CES1 | |
| SCHEMBL1365349 | 0.80 | GSK3B (0.61) | GSK3BPTPN1CES2CES1THRA | |
| SCHEMBL2776629 | 0.78 | GSK3B (0.63) | GSK3BPTPN1THRATHRB | |
| SCHEMBL6631999 | 0.78 | GSK3B (0.59) | GSK3BPTPN1CES2CES1 | |
| SCHEMBL16057598 | 0.78 | PTPN1 (0.63) | GSK3BPTPN1CES2CES1THRA | |
| SCHEMBL14532029 | 0.77 | GSK3B (0.64) | GSK3BPTPN1HDAC3HDAC4HDAC1 | |
| SCHEMBL392969 | 0.77 | GSK3B (0.59) | GSK3BPTPN1 | |
| SCHEMBL13557299 | 0.77 | GSK3B (0.68) | GSK3BPTPN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160368883-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2016-12-22 | — | — | US | disclosed |
| US-9456605-B2 | Isoxazoline derivatives as insecticides | SYNGENTA CROP PROTECTION, LLC (US) | 2016-10-04 | — | — | US | disclosed |
| US-20140249316-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2014-09-04 | — | — | US | disclosed |
| US-8754053-B2 | Isoxazoline derivatives as insecticides | SYNGENTA CROP PROTECTION LLC (US) | 2014-06-17 | — | — | US | disclosed |
| US-20120316124-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2012-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249316-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | ACHE, CHRM1, ITPR3 | GSK3B 2612/4885PTPN1 2475/4885CES2 1982/4885 |
| US-20120316124-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | CHRM1, ACHE, P2RX7 | GSK3B 2623/4885PTPN1 2377/4885CES2 1869/4885 |
| US-20160368883-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | ACHE, CHRM1, ITPR3 | GSK3B 2612/4885PTPN1 2475/4885CES2 1982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.