Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GPX4 | P36969 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229231 | 0.91 | L3MBTL1 (0.40) | OGG1L3MBTL1LMNAPOLBTP53 | |
| SCHEMBL14229073 | 0.87 | L3MBTL1 (0.41) | OGG1L3MBTL1LMNAPOLBTP53 | |
| SCHEMBL14200990 | 0.87 | RIPK1 (0.37) | OGG1L3MBTL1LMNACYP1A2POLB | |
| SCHEMBL14229132 | 0.86 | ALDH1A1 (0.49) | L3MBTL1LMNATP53ALDH1A1NPC1 | |
| SCHEMBL14229300 | 0.86 | OGG1 (0.42) | OGG1L3MBTL1LMNACYP1A2POLB | |
| SCHEMBL14229379 | 0.85 | ALDH1A1 (0.42) | ALDH1A1NPC1 | |
| SCHEMBL14229125 | 0.85 | MAPK1 (0.39) | L3MBTL1TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL14228936 | 0.84 | LTB4R2 (0.47) | L3MBTL1POLBTP53NPC1RAB9A | |
| SCHEMBL14229204 | 0.84 | TP53 (0.37) | TP53MTNR1BALDH1A1NPC1RAB9A | |
| SCHEMBL14230173 | 0.83 | L3MBTL1 (0.42) | OGG1L3MBTL1LMNACYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |