Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | OGG1 | O15527 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | CTSG | P08311 | 2/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.34 |
| ▸ | CMA1 | P23946 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200978 | 0.92 | RIPK1 (0.39) | RIPK1TP53BP1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL14200481 | 0.87 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL14200995 | 0.87 | RIPK1 (0.39) | RIPK1TP53BP1L3MBTL1OGG1PRSS1 | |
| SCHEMBL14229244 | 0.87 | OGG1 (0.40) | L3MBTL1OGG1ALDH1A1LMNAPOLB | |
| SCHEMBL14201068 | 0.87 | RIPK1 (0.40) | RIPK1TP53BP1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL14200432 | 0.86 | EPHX2 (0.41) | RIPK1ALDH1A1SMN1; SMN2MAPTNPSR1 | |
| SCHEMBL14200442 | 0.86 | MAPK1 (0.37) | L3MBTL1ALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL14200514 | 0.85 | LTB4R2 (0.42) | PRSS1CTSGCTRB1CMA1MEN1 | |
| SCHEMBL14200470 | 0.85 | REN (0.36) | PRSS1CTSGCTRB1CMA1ALDH1A1 | |
| SCHEMBL14201000 | 0.84 | RIPK1 (0.40) | RIPK1TP53BP1L3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |