Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.41 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.41 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.41 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.41 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | CACNA1E | Q15878 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2541898 | 0.92 | GPR119 (0.45) | SMN1; SMN2GPR119CACNB4CACNA1ACACNA1G | |
| SCHEMBL2538429 | 0.92 | GPR119 (0.46) | SMN1; SMN2GPR119CACNB4CACNA1ACACNA1G | |
| SCHEMBL2541926 | 0.87 | GPR119 (0.46) | SMN1; SMN2GPR119CACNB4CACNA1ACACNA1G | |
| SCHEMBL14237487 | 0.85 | GPR119 (0.45) | SMN1; SMN2GPR119TOP2ACACNB4CACNA1A | |
| SCHEMBL2546749 | 0.81 | FPR2 (0.37) | SMN1; SMN2GPR119 | |
| SCHEMBL13718678 | 0.79 | GPR119 (0.66) | GPR119TOP2APDE4DPDE4APDE4B | |
| SCHEMBL14237483 | 0.79 | GPR119 (0.49) | GPR119 | |
| SCHEMBL1550872 | 0.78 | NPBWR1 (0.50) | GPR119TOP2ACACNB4CACNA1ACACNA1G | |
| SCHEMBL14237663 | 0.78 | GPR119 (0.61) | GPR119 | |
| SCHEMBL29079749 | 0.77 | GPR119 (0.58) | GPR119TOP2APDE4DPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |