Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2036823 | 0.77 | MCHR1 (0.57) | MAOAMAOBPDE10ACYP19A1HSP90AA1 | |
| SCHEMBL10904420 | 0.77 | GAA (0.47) | ALDH1A1LMNACYP3A4TSHRMEN1 | |
| SCHEMBL728248 | 0.76 | MAOA (0.64) | MAOAMAOBP2RX4CYP11B1CYP11B2 | |
| SCHEMBL1672334 | 0.76 | PDE10A (0.57) | MAOAMAOBPDE10ACYP19A1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL1901179 | 0.75 | MAOA (0.63) | MAOAMAOBP2RX4CYP11B1CYP11B2 | |
| SCHEMBL3192555 | 0.75 | ALDH1A1 (0.52) | MAOAMAOBCYP19A1HSP90AA1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28789582 | 0.74 | PDE10A (0.56) | MAOAMAOBPDE10ACYP19A1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL2953393 | 0.74 | PDE10A (0.56) | MAOAMAOBPDE10ACYP19A1HSP90AA1 | |
| SCHEMBL38654702 | 0.72 | AR (0.49) | MAOAMAOBPDE10AKCNN4HSP90AA1 | |
| SCHEMBL9731132 | 0.70 | KCNN4 (0.47) | P2RX4KCNN4ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315588-B1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW MAO INHIBITORS AND IMIDAZOLINE RECEPTOR LIGANDS | ROTTAPHARM SPA (IT) | 2012-12-19 | — | — | EP | claimed |