Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | LATS1 | O95835 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14239061 | 0.89 | BACE1 (0.40) | RAB9ANPC1L3MBTL1TDP1 | |
| SCHEMBL14239054 | 0.85 | RAB9A (0.37) | RAB9ANPC1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL14239376 | 0.85 | L3MBTL1 (0.40) | RAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14239058 | 0.84 | METAP2 (0.40) | RAB9ANPC1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL14239056 | 0.84 | RAB9A (0.38) | RAB9ANPC1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL14239819 | 0.83 | RAB9A (0.38) | RAB9ANPC1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL15835029 | 0.83 | GRM5 (0.37) | RAB9ANPC1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL14239342 | 0.82 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL14239355 | 0.82 | L3MBTL1 (0.43) | RAB9ANPC1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL14239122 | 0.82 | RAB9A (0.38) | RAB9ANPC1SMN1; SMN2LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170845-A2 | METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | HEFFERNAN MICHELE L R (US) | 2012-12-13 | — | — | WO | disclosed |