Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14239376 | 0.92 | L3MBTL1 (0.40) | L3MBTL1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL14239342 | 0.89 | RAB9A (0.45) | L3MBTL1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14239053 | 0.88 | L3MBTL1 (0.42) | L3MBTL1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL14239061 | 0.88 | BACE1 (0.40) | L3MBTL1NPC1RAB9ATDP1DHODH | |
| SCHEMBL14239057 | 0.87 | RAB9A (0.37) | L3MBTL1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL14239058 | 0.87 | METAP2 (0.40) | L3MBTL1NPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL14239051 | 0.86 | RAB9A (0.40) | L3MBTL1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL14239132 | 0.85 | ALDH1A1 (0.44) | L3MBTL1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6921870 | 0.85 | RAB9A (0.40) | L3MBTL1LRRK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14238974 | 0.85 | L3MBTL1 (0.39) | L3MBTL1LRRK2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170845-A2 | METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | HEFFERNAN MICHELE L R (US) | 2012-12-13 | — | — | WO | disclosed |