SCHEMBL14239271

SCHEMBL14239271

C[S+]([O-])c1ccc(-n2cnc(C(=O)O)c2)c(F)c1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.40
USP30 Q70CQ3 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14167774 0.79 GPR119 (0.41) KDM4E
SCHEMBL4425274 0.78 KMO (0.47) KDM4E
SCHEMBL14239715 0.78 KDM4E (0.42) KDM4E
SCHEMBL14240129 0.77 GABRA2 (0.39)
SCHEMBL14167843 0.74 NR3C2 (0.41)
SCHEMBL29367242 0.74 KDM4E (0.49) KDM4E
SCHEMBL20162909 0.74 KDM4E (0.49) KDM4E
SCHEMBL27603200 0.69 KDM4E (0.42) KDM4E
SCHEMBL21330974 0.69 SLC6A9 (0.46) KDM4E
SCHEMBL21330959 0.69 SLC6A9 (0.46) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012168315-A1 SUBSTITUTED PIPERIDINES AS GPR119 MODULATORS FOR THE TREATMENT OF METABOLIC DISORDERS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-12-13 WO disclosed