Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 4/20 | 0.34 |
| ▸ | THRB | P10828 | 4/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18995991 | 0.81 | ALDH1A1 (0.45) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL1356766 | 0.80 | ALDH1A1 (0.50) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL15942700 | 0.79 | ALDH1A1 (0.39) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL12837225 | 0.77 | THRB (0.56) | ALDH1A1HIF1ACYP3A4SMN1; SMN2HPGD | |
| SCHEMBL14239796 | 0.76 | MGLL (0.43) | ALDH1A1HIF1ACYP3A4SMN1; SMN2HPGD | |
| SCHEMBL2152056 | 0.75 | ALDH1A1 (0.37) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL19677578 | 0.75 | HPGD (0.36) | HPGDPPARGTHRATHRBKCNA3 | |
| SCHEMBL1357523 | 0.74 | ALDH1A1 (0.47) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL2832821 | 0.74 | ALDH1A1 (0.47) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL9816004 | 0.74 | ALDH1A1 (0.54) | ALDH1A1TP53TSHRHIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9220788-B2 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof | NANOPHARMACEUTICALS LLC (US) | 2015-12-29 | — | — | US | disclosed |
| US-8802240-B2 | Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells | NANOPHARMACEUTICALS LLC (US) | 2014-08-12 | — | — | US | disclosed |
| EP-2662079-A1 | Uses of formulations of thyroid hormone antagonists and nanoparticulate forms thereof to increase chemosensivity and radiosensitivity in tumor or cancer cells | Ordway Research Institute, Inc. (US) | 2013-11-13 | — | — | EP | disclosed |
| US-20120315320-A1 | USES OF FORMULATIONS OF THYROID HORMONE ANALOGS AND NANOPARTICULATE FORMS THEREOF TO INCREASE CHEMOSENSIVITY AND RADIOSENSITIVITY IN TUMOR OR CANCER CELLS | NANOPHARMACEUTICALS LLC | 2012-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120315320-A1 | USES OF FORMULATIONS OF THYROID HORMONE ANALOGS AND NANOPARTICULATE FORMS THEREOF TO INCREASE CHEMOSENSIVITY AND RADIOSENSITIVITY IN TUMOR OR CANCER CELLS | TSHR, TPO, THRA | ALDH1A1 1493/4885TP53 12/4885TSHR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.