Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | GYS1 | P13807 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30762653 | 0.78 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1TSHRUCHL1L3MBTL1 | |
| SCHEMBL5690458 | 0.78 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1TSHRUCHL1L3MBTL1 | |
| SCHEMBL28510227 | 0.75 | PREP (0.48) | SMN1; SMN2ALDH1A1TSHRUCHL1CHRM2 | |
| SCHEMBL29074159 | 0.75 | PREP (0.48) | SMN1; SMN2ALDH1A1TSHRUCHL1CHRM2 | |
| SCHEMBL30616301 | 0.73 | RAB9A (0.49) | SMN1; SMN2ALDH1A1MAPK1KDM4ENPSR1 | |
| SCHEMBL7112033 | 0.73 | PNMT (0.42) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL7112036 | 0.73 | PNMT (0.42) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL8840922 | 0.72 | RAB9A (0.54) | SMN1; SMN2ALDH1A1MAPK1KDM4ENPSR1 | |
| SCHEMBL7022249 | 0.72 | TP53 (0.42) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1POLB | |
| SCHEMBL2747664 | 0.71 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1MAPK1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160333054-A1 | SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS | NIH - DEITR | 2016-11-17 | — | — | US | disclosed |
| US-9260484-B2 | Small molecule composite surfaces as inhibitors of protein-protein interactions | OHIO STATE INNOVATION FOUNDATION (US) | 2016-02-16 | — | — | US | disclosed |
| US-20140200186-A1 | SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS | NIH - DEITR | 2014-07-17 | — | — | US | disclosed |
| WO-2012174489-A2 | SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS | THE OHIO STATE UNIVERSITY (US) | 2012-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200186-A1 | SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS | PAIP1, ECPAS, AIP | SMN1; SMN2 4461/4885ALDH1A1 4768/4885MAPK1 2632/4885 |
| US-20160333054-A1 | SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS | PAIP1, ECPAS, AIP | SMN1; SMN2 4461/4885ALDH1A1 4768/4885MAPK1 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.