Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080245 | 0.82 | POLB (0.59) | MEN1KMT2AALDH1A1HPGDAPOBEC3A | |
| SCHEMBL18361600 | 0.78 | ALOX5 (0.60) | KMT2AALDH1A1HPGDPOLB | |
| SCHEMBL11860231 | 0.76 | HDAC1 (0.61) | MTNR1AMTNR1B | |
| SCHEMBL11863210 | 0.75 | CNR1 (0.50) | CYP19A1 | |
| SCHEMBL14255245 | 0.75 | MTNR1A (0.40) | MEN1KMT2AALDH1A1MTNR1AESR1 | |
| SCHEMBL4868917 | 0.74 | ESR1 (0.43) | MEN1KMT2AALDH1A1MTNR1AESR1 | |
| SCHEMBL27715804 | 0.73 | THRB (0.57) | MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL21894227 | 0.73 | TAAR1 (0.49) | MEN1KMT2AALDH1A1HPGDPOLB | |
| SCHEMBL12330476 | 0.73 | ESR1 (0.42) | MEN1KMT2AALDH1A1MTNR1AESR1 | |
| SCHEMBL11870626 | 0.73 | HDAC1 (0.57) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345035-B2 | Treatment of osteoporosis and autoimmune disease with astrogorgiadiol | UNIVERSITY OF DELAWARE (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345035-B2 | Treatment of osteoporosis and autoimmune disease with astrogorgiadiol | UNIVERSITY OF DELAWARE (US) | 2008-03-18 | — | — | US | disclosed |