Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 9/20 | 0.47 |
| ▸ | KDM1A | O60341 | 4/20 | 0.47 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.45 |
| ▸ | WHR1 | P49842 | 1/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14412273 | 0.90 | EHMT2 (0.44) | EHMT2KDM1ADNMT3AWHR1RCOR1 | |
| SCHEMBL14256736 | 0.87 | DNMT3A (0.53) | EHMT2KDM1ADNMT3AWHR1RCOR1 | |
| SCHEMBL14266659 | 0.87 | EHMT2 (0.42) | EHMT2KDM1ADNMT3AWHR1RCOR1 | |
| SCHEMBL14256741 | 0.85 | WHR1 (0.45) | EHMT2KDM1ADNMT3AWHR1APP | |
| SCHEMBL14256444 | 0.84 | MERTK (0.53) | WHR1APPBCHEACHEMERTK | |
| SCHEMBL14412253 | 0.84 | PDE5A (0.45) | EHMT2KDM1ADNMT3AWHR1APP | |
| SCHEMBL14256699 | 0.83 | MERTK (0.52) | APPBCHEACHEMERTKCXCR4 | |
| SCHEMBL14412248 | 0.82 | APP (0.45) | EHMT2KDM1AWHR1APPBCHE | |
| SCHEMBL14412272 | 0.82 | CXCR4 (0.52) | WHR1APPBCHEACHEMERTK | |
| SCHEMBL14256700 | 0.82 | APP (0.46) | EHMT2KDM1AWHR1APPBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058312-A1 | Modulators of hepatocyte growth factor/c-Met activity | ANGION BIOMEDICA CORPORATION (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058312-A1 | Modulators of hepatocyte growth factor/c-Met activity | ANGION BIOMEDICA CORPORATION (US) | 2008-03-06 | — | — | US | disclosed |
| US-20070213319-A1 | Modulators of hepatocyte growth factor/c-Met activity | ANGION BIOMEDICA CORPORATION (US) | 2007-09-13 | — | — | US | disclosed |
| US-20070213319-A1 | Modulators of hepatocyte growth factor/c-Met activity | ANGION BIOMEDICA CORPORATION (US) | 2007-09-13 | — | — | US | disclosed |
| WO-2007081978-A2 | MODULATORS OF HEPATOCYTE GROWTH FACTOR / C-MET ACTIVITY | ANGION BIOMEDICA CORPORATION (US) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213319-A1 | Modulators of hepatocyte growth factor/c-Met activity | HGF, MET, HDGF | EHMT2 1276/4885KDM1A 3012/4885DNMT3A 1041/4885 |
| US-20080058312-A1 | Modulators of hepatocyte growth factor/c-Met activity | HGF, MET, HDGF | EHMT2 1177/4885KDM1A 2734/4885DNMT3A 832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.